CRK and RET

Data Source:
HPRD (in vitro)

		CRK	RET
Description		CRK proto-oncogene, adaptor protein	ret proto-oncogene
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Actin Cytoskeleton Membrane Protein-containing Complex Membrane Raft Extracellular Exosome	Early Endosome Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane Axon Dendrite Neuronal Cell Body Receptor Complex Membrane Raft Plasma Membrane Protein Complex
	Molecular Function	Phosphotyrosine Residue Binding Insulin-like Growth Factor Receptor Binding Protein Binding Cytoskeletal Protein Binding SH3 Domain Binding Kinase Binding Signaling Receptor Complex Adaptor Activity Ubiquitin Protein Ligase Binding Signaling Adaptor Activity SH2 Domain Binding Protein Self-association Protein Phosphorylated Amino Acid Binding Ephrin Receptor Binding Scaffold Protein Binding Protein Tyrosine Kinase Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Calcium Ion Binding Protein Binding ATP Binding Signaling Receptor Activity
	Biological Process	Activation Of MAPKK Activity Neuron Migration Response To Yeast Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Regulation Of Cell Shape Regulation Of Signal Transduction Positive Regulation Of Smooth Muscle Cell Migration Dendrite Development Cytokine-mediated Signaling Pathway Hippocampus Development Cerebral Cortex Development Establishment Of Cell Polarity Actin Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Rac Protein Signal Transduction Helper T Cell Diapedesis Response To Hepatocyte Growth Factor Reelin-mediated Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Response To Hydrogen Peroxide Regulation Of GTPase Activity Regulation Of Protein Binding Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Dendrite Development Cell Chemotaxis Negative Regulation Of Wound Healing Response To Cholecystokinin Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Nitric Oxide Activation Of GTPase Activity Cerebellar Neuron Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Intracellular Signal Transduction Cellular Response To Nerve Growth Factor Stimulus Cellular Response To Insulin-like Growth Factor Stimulus Cellular Response To Endothelin Negative Regulation Of Cell Motility Regulation Of T Cell Migration	MAPK Cascade Activation Of MAPK Activity Ureteric Bud Development Neural Crest Cell Migration Embryonic Epithelial Tube Formation Protein Phosphorylation Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Neuron Cell-cell Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Posterior Midgut Development Positive Regulation Of Neuron Projection Development Positive Regulation Of Neuron Maturation Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Membrane Protein Proteolysis Positive Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Kinase Activity Ureter Maturation Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Response To Drug Neuron Maturation Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Size Positive Regulation Of Transcription, DNA-templated Response To Pain Enteric Nervous System Development Regulation Of Axonogenesis Positive Regulation Of Protein Kinase B Signaling Retina Development In Camera-type Eye Innervation Peyer's Patch Morphogenesis Cellular Response To Retinoic Acid Positive Regulation Of Metanephric Glomerulus Development Lymphocyte Migration Into Lymphoid Organs Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		ARMS-mediated activation ARMS-mediated activation Downstream signal transduction Regulation of actin dynamics for phagocytic cup formation p130Cas linkage to MAPK signaling for integrins VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases MET activates RAP1 and RAC1 MET receptor recycling Regulation of signaling by CBL FCGR3A-mediated phagocytosis	RAF/MAP kinase cascade RET signaling
Drugs			Sorafenib 1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Vandetanib Cabozantinib Regorafenib Ponatinib Lenvatinib Fostamatinib Amuvatinib Selpercatinib Pralsetinib
Diseases			Hirschsprung disease (HD) Renal agenesis and Renal adysplasia Thyroid cancer Congenital central hypoventilation syndrome (CCHS)
GWAS		Atrial fibrillation ( 30061737) Granulocyte count ( 27863252) Intraocular pressure ( 30591961) Lymphocyte percentage of white cells ( 32888494 27863252) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Pulse pressure ( 27841878) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systolic blood pressure ( 28135244 27841878 30578418)	Blood protein levels ( 30072576 29875488 28240269) Cannabis dependence symptom count ( 27028160) Hirschsprung disease ( 19196962 30031151 25310821 29379196 27702942) Smoking behaviour (cigarettes smoked per day) ( 31089300)
Interacting Genes		169 interacting genes: ABL1 ABL2 ANKZF1 ANLN AR ARHGAP17 ARHGAP32 ASAP1 ASAP3 ASCL4 ATF3 ATXN1 AVIL BATF3 BCAR1 BCR BEX5 BUB1 C1orf94 C4orf17 C6orf141 CBL CBLB CBLC CHTF18 CLNK CNDP2 CORO6 CRKL DAB1 DOCK1 DOCK3 DOK1 DOK2 DOK3 DOK4 DOK7 DPPA4 EFS EGFR ELK1 ELK3 EPHA3 EPHB2 EPHB3 EPHB6 EPS15 EPYC ERBB2 ERBB3 ERBB4 ESD EYA3 FASLG FER FGFR1 FLACC1 FLT1 FRS2 FSTL1 FYN GAB1 GABPB2 GAREM1 GRB2 HABP4 HSH2D IFT140 IGF1R IKZF3 INO80E INSR IRS1 IRS2 IRS4 ISL1 KCTD13 KCTD17 KDR KHDRBS1 KIT KLF15 KLHL20 LASP1 LHX8 LNX2 MAGEC3 MAP4K1 MAP4K5 MAPK4 MAPK8 MET MICAL1 MNDA MPG MYLIP MYOZ2 NCK1 NEDD9 NTRK1 NUFIP2 OFCC1 PAFAH1B2 PDGFRA PDGFRB PHC2 PIK3R1 PIK3R2 PIK3R3 PLSCR1 POT1 PPFIBP2 PPP1CA PRKACA PRRC2B PRRG2 PSMC1 PSMC6 PTK2 PTK2B PTPN1 PTPN4 PTPRH PTTG1 PXN RAB2B RAPGEF1 REPS1 RET RIN3 RTCB RYBP SASH1 SAXO1 SEMA4D SEPTIN6 SETD9 SH2D2A SH3BP1 SHB SHC1 SOCS1 SOCS6 SOS1 SPRR2A STAT4 STAT5A STAT5B STRN4 SYN1 TCAP TDG TERF2IP TM4SF19 TP53 TP53BP2 TUBA1C TWIST2 TXK USP53 VAC14 VAV1 WASF1 WDR83 WEE1 XPO1 ZAP70 ZKSCAN7 ZNF557	44 interacting genes: AKAP5 CBL CBLB CRK DOK1 DOK2 DOK3 DOK4 DOK5 DOK6 DUSP26 ERBB2 FBXO7 FRS2 GAB1 GDNF GFRA1 GRB10 GRB2 GRB7 IKBKG LRRK1 MAPK1 MAPK14 MAPK3 MAPK8 NEDD4 NOTCH2NLA NOTCH3 NRTN PDLIM7 PIK3R1 PLCG1 PRKAR2A PTK2 PTPN11 PTPRA PTPRF PTPRR SHC1 SHC3 SHC4 SRC STAT3
Entrez ID		1398	5979
HPRD ID		01267	01266
Ensembl ID		ENSG00000167193	ENSG00000165731
Uniprot IDs		A0A0S2Z3K9 A0A0S2Z3Q4 L7RT18 P46108	A0A024R7T2 P07949
PDB IDs		1JU5 2DVJ 2EYV 2EYW 2EYX 2EYY 2EYZ 2MS4 5UL6 6ATV	1XPD 2IVS 2IVT 2IVU 2IVV 2X2K 2X2L 2X2M 2X2U 4CKI 4CKJ 4UX8 5AMN 5FM2 5FM3 6FEK 6GL7 6I82 6I83 6NE7 6NEC 6NJA 6Q2J 6Q2N 6Q2O 6Q2R 6Q2S 6VHG
Enriched GO Terms of Interacting Partners?
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