KDM4D and CEP76

Data Source:
BioGRID (two hybrid)

		KDM4D	CEP76
Description		lysine demethylase 4D	centrosomal protein 76
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Pericentric Heterochromatin Site Of Double-strand Break Blood Microparticle	Centrosome Centriole Cytosol Protein-containing Complex
	Molecular Function	Damaged DNA Binding Protein Binding Chromatin DNA Binding Histone Demethylase Activity Histone Demethylase Activity (H3-K9 Specific) Metal Ion Binding Dioxygenase Activity	Protein Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination Regulation Of Protein Phosphorylation Chromatin Remodeling Histone H3-K9 Demethylation Positive Regulation Of Chromatin Binding Cellular Response To Ionizing Radiation Negative Regulation Of Histone H3-K9 Trimethylation Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	G2/M Transition Of Mitotic Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Centriole Replication Ciliary Basal Body-plasma Membrane Docking
Pathways		HDMs demethylate histones	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Diabetic kidney disease ( 26305897)
Interacting Genes		4 interacting genes: CEP76 LRRK2 PPP1CC TP53	105 interacting genes: AKAP7 AKT1 ANKRD36 ASH2L BANP C22orf39 CABP5 CACNB3 CAPN3 CAVIN3 CCDC92 CCNK CDK18 CENPI CIR1 COIL CRYBA4 CSNK1G1 CUTC CWF19L2 DCTD DDX6 DEAF1 DMTN DVL3 DZIP1L EAF1 EIF1AD EP400P1 ERCC3 FAM90A1 GDAP2 GFAP GORASP2 HSF2 HSPB7 ILVBL IQUB KDM1A KDM4D KIAA1143 KIFBP KLHDC4 L3MBTL2 LATS1 LNX1 MAGEA11 MBD3 MFAP1 MISP MLH1 MYOZ1 NEK6 NFYC NHLRC2 NME5 PAICS PARD6B PATZ1 PDGFRB PDRG1 PDZD4 PDZD7 PIN1 PKP1 PLA2G6 PLCB1 POM121 RADIL RALGPS1 RBM41 RIPPLY3 RNF128 RPL9 SALL2 SCNM1 SH2D4A SINHCAF SMG9 SPG21 STK26 SUOX TBC1D27P TCEA2 TCEANC TCF19 TFAP2D THRA TOB2 TSPOAP1 TSSC4 TTC21A TTLL10 TUFT1 TXNDC9 VEZF1 WDFY3 YY1 ZBTB24 ZBTB4 ZMAT2 ZNF185 ZNF653 ZNF76 ZNF85
Entrez ID		55693	79959
HPRD ID		17169	12694
Ensembl ID		ENSG00000186280	ENSG00000101624
Uniprot IDs		Q6B0I6	B4DP81 Q8TAP6
PDB IDs		3DXT 3DXU 4D6Q 4D6R 4D6S 4HON 4HOO 5F5A 5F5C 5FP4 5FP7 5FP8 5FP9 5FPA 5FPB 5PH0 5PH1 5PH2 5PH3 5PH4 5PH5 5PH6 5PH7 5PH8 5PH9 5PHA 5PHB 5PHC 5PHD 5PHE 5PHF 5PHG 5PHH 5PHI 5PHJ 5PHK 5PHL 5PHM 5PHN 5PHO 5PHP 5PHQ 5PHR 5PHS 5PHT 5PHU 5PHV 5PHW 5PHX 5PHY 5PHZ 5PI0 5PI1 5PI2 5PI3 5PI4 5PI5 5PI6 5PI7 5PI8 5PI9 5PIA 5PIB 5PIC 5PID 5PIE 5PIF 5PIG 5PIH 5PII 5PIJ 5PIK 5PIL 5PIM 5PIN 5PIO 5PIP 5PIQ 5PIR 5PIS 5PIT 5PIU 5PIV 5PIW 5PIX 5PIY 5PIZ 5PJ0 5PJ1 5PJ2 5PJ3 5PJ4 5PJ5 5PJ6 5PJ7 5PJ8 5PJ9 5PJA 5PJB 5PJC 5PJD 5PJE 5PJF 5PJG 5PJH 5PJI 5PJJ 5PJK 5PJL 5PJM 5PJN 5PJO 5PJP 5PJQ 5PJR 5PJS 5PJT 5PJU 5PJV 5PJW 5PJX 5PJY 5PJZ 5PK0 5PK1 5PK2 5PK3 5PK4 5PK5 5PK6 5PK7 5PK8 5PK9 5PKA 5PKB 5PKC 5PKD 5PKE 5PKF 5PKG 5PKH 5PKI 5PKJ 5PKK 5PKL 5PKM 5PKN 5PKO 5PKP 5PKQ 5PKR 5PKS 5PKT 5PKU 5PKV 5PKW 5PKX 5PKY 5PKZ 5PL0 5PL1 5PL2 5PL3 5PL4 5PL5 5PL6 5PL7 5PL8 5PL9 5PLA 5PLB 5PLC 5PLD 5PLE 5PLF 5PLG 5PLH 5PLI 5PLJ 5PLK 5PLL 5PLM 5PLN 5PLO 5PLP 5PLQ 5PLR 5PLS 5PLT 5PLU 5PLV 5PLW 5PLX 5PLY 5PLZ 5PM0 5PM1 5PM2 5PM3 5PM4 5PM5 5PM6 5PM7 5PM8 5PM9 5PMA 5PMB 5PMC 5PMD 5PME 5PMF 5PMG 5PMH 5PMI 5PMJ 5PMK 5PML 5PMM 5PMN 5PMO 5PMP 5PMQ 5PMR 5PMS 5PMT 5PMU 5PMV 5PMW 5PMX 5PMY 5PMZ 5PN0 5PN1 5PN2 5PN3 5PN4 5PN5 5PN6 5PN7 5PN8 5PN9 5PNA 5PNB 5PNC 5PND 5PNE 5PNF 5PNG 5PNH 5PNI 5PNJ 5PNK 5PNL 5PNM 5PNN 5PNO 5PNP 5PNQ 5PNR 5PNS 5PNU 5PNV 5PNW 6ETE 6ETG 6ETS 6ETT 6ETU 6ETV 6ETW 6F5Q 6F5R 6F5S 6F5T 6H0W 6H0X 6H0Y 6H0Z 6H10 6H11
Enriched GO Terms of Interacting Partners?
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