GGA3 and RNF11

Data Source:
HPRD (two hybrid)

		GGA3	RNF11
Description		golgi associated, gamma adaptin ear containing, ARF binding protein 3	ring finger protein 11
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Golgi Apparatus Trans-Golgi Network Endosome Membrane Early Endosome Membrane Protein-containing Complex Recycling Endosome Membrane	Ubiquitin Ligase Complex Nucleus Early Endosome Recycling Endosome Extracellular Exosome
	Molecular Function	Protein Binding Small GTPase Binding Ubiquitin Binding Protein-containing Complex Binding	DNA Binding Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Targeting To Lysosome Intracellular Protein Transport Regulation Of Protein Stability Protein Destabilization Endocytic Recycling Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport Cellular Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Amyloid-beta Formation	Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination
Pathways		TBC/RABGAPs MET receptor recycling Amyloid fiber formation
Drugs
Diseases
GWAS			Atrial fibrillation ( 29290336) Male-pattern baldness ( 28196072) QRS duration ( 21076409)
Interacting Genes		38 interacting genes: ADRA2A ADRA2B AFTPH AP1S2 ARAP3 ARF1 ARF3 CDKN2A CLINT1 CLTC CYTH2 DAZAP2 EGFR GGA1 GGA2 IGF2R LITAF LRP10 M6PR P4HA3 PACS1 PLEKHB2 RABEP1 RNF11 RNF214 RPS27A STAB1 SYNRG TBC1D3 TOLLIP TRAPPC6A TRIM23 TSG101 UBC UPRT VPS11 VPS18 ZNF497	68 interacting genes: AKT1 ANKRD13A ANKRD28 APP ASCC2 AUP1 CALCOCO2 CBLB CCDC127 DCUN1D1 EPN1 EPN2 EPN3 EPS15 ERCC6 FANCL GGA1 GGA2 GGA3 HERC1 HERC2 HUWE1 IKBKG ITCH MYO6 NEDD4 NEDD4L OPTN PDCD6IP POLI PTPRC QARS1 RABGEF1 RIPK1 RNF168 RNF216 RPS27A SDCBP SMURF1 SMURF2 SNRNP70 SPRTN STAM2 STAMBP TAX1BP1 TNFAIP3 TNIP1 TOM1L2 UBA52 UBAC1 UBB UBC UBE2D1 UBE2D2 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2U UBQLN2 UBQLN4 USP5 WWP1 WWP2 ZFYVE16 ZFYVE9 ZNF350
Entrez ID		23163	26994
HPRD ID		10443	09955
Ensembl ID		ENSG00000125447	ENSG00000123091
Uniprot IDs		A8K6M0 B7Z456 Q9NZ52	Q9Y3C5
PDB IDs		1JPL 1JUQ 1LF8 1P4U 1WR6 1YD8
Enriched GO Terms of Interacting Partners?
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