PRKACA and RHOA

Data Source:
HPRD (in vitro, in vivo)

		PRKACA	RHOA
Description		protein kinase cAMP-activated catalytic subunit alpha	ras homolog family member A
Image
GO Annotations	Cellular Component	Acrosomal Vesicle Nucleus Nucleoplasm Cytoplasm Mitochondrion Centrosome Cytosol Axoneme CAMP-dependent Protein Kinase Complex Membrane Nuclear Speck Neuromuscular Junction Calcium Channel Complex Sperm Flagellum Dendritic Spine Plasma Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Ciliary Base	Endosome Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Lamellipodium Cell Junction Midbody Secretory Granule Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytoplasmic Vesicle Vesicle Cleavage Furrow Cell Projection Dendritic Spine Intracellular Membrane-bounded Organelle Apical Junction Complex Extracellular Exosome Cell Periphery Postsynapse Glutamatergic Synapse Ficolin-1-rich Granule Membrane
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Domain Specific Binding Manganese Ion Binding Ubiquitin Protein Ligase Binding Protein Kinase A Regulatory Subunit Binding	GTPase Activity Protein Binding GTP Binding Myosin Binding Protein Kinase Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mesoderm Formation Neural Tube Closure Regulation Of Heart Rate Stimulatory C-type Lectin Receptor Signaling Pathway Renal Water Homeostasis MRNA Processing Protein Phosphorylation Blood Coagulation Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Kinase A Signaling Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cytokine-mediated Signaling Pathway Activation Of Protein Kinase A Activity High-density Lipoprotein Particle Assembly Cellular Response To Heat Calcium-mediated Signaling Using Intracellular Calcium Source Regulation Of Protein Binding Regulation Of Osteoblast Differentiation Protein Autophosphorylation Positive Regulation Of Protein Export From Nucleus Sperm Capacitation Modulation Of Chemical Synaptic Transmission Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Cardiac Muscle Contraction Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Processing Positive Regulation Of Cell Cycle Arrest Cellular Response To Glucose Stimulus Cellular Response To Parathyroid Hormone Stimulus Cellular Response To Glucagon Stimulus Cellular Response To Epinephrine Stimulus Cell Communication By Electrical Coupling Involved In Cardiac Conduction Ciliary Basal Body-plasma Membrane Docking Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Regulation Of Cardiac Conduction Regulation Of Bicellular Tight Junction Assembly	Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Transforming Growth Factor Beta Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Regulation Of Cell Shape Negative Regulation Of Cell-substrate Adhesion Viral Process Cell Migration Protein Deubiquitination Substantia Nigra Development Actin Cytoskeleton Organization Regulation Of Cell Migration Cortical Cytoskeleton Organization Cytoplasmic Microtubule Organization Actin Cytoskeleton Reorganization Positive Regulation Of Cytokinesis Regulation Of Actin Cytoskeleton Organization Regulation Of Osteoblast Proliferation Cell Junction Assembly Substrate Adhesion-dependent Cell Spreading Roundabout Signaling Pathway Cleavage Furrow Formation Apolipoprotein A-I-mediated Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Stress Fiber Assembly Apical Junction Assembly Neutrophil Degranulation Endothelial Cell Migration Ossification Involved In Bone Maturation Wound Healing, Spreading Of Cells Establishment Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Neuron Differentiation Negative Regulation Of Cell Size Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Negative Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Negative Chemotaxis Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Lipase Activity Trabecula Morphogenesis Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Mitotic Spindle Assembly Endothelial Tube Lumen Extension Positive Regulation Of NIK/NF-kappaB Signaling Skeletal Muscle Satellite Cell Migration Mitotic Cleavage Furrow Formation Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Cellular Response To Chemokine Regulation Of Cell Motility Positive Regulation Of T Cell Migration
Pathways		PKA-mediated phosphorylation of CREB PKA-mediated phosphorylation of key metabolic factors Triglyceride catabolism PKA activation PKA activation in glucagon signalling DARPP-32 events Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins VEGFA-VEGFR2 Pathway CREB1 phosphorylation through the activation of Adenylate Cyclase CREB1 phosphorylation through the activation of Adenylate Cyclase Interleukin-3, Interleukin-5 and GM-CSF signaling Ion homeostasis Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'off' state Anchoring of the basal body to the plasma membrane CD209 (DC-SIGN) signaling MAPK6/MAPK4 signaling RET signaling AURKA Activation by TPX2 HDL assembly ROBO receptors bind AKAP5 Loss of phosphorylation of MECP2 at T308 Regulation of MECP2 expression and activity Regulation of glycolysis by fructose 2,6-bisphosphate metabolism ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production	GPVI-mediated activation cascade Axonal growth inhibition (RHOA activation) Rho GTPase cycle PI3K/AKT activation Axonal growth stimulation TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) G beta:gamma signalling through PI3Kgamma EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse PCP/CE pathway G alpha (12/13) signalling events Sema4D mediated inhibition of cell attachment and migration Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse VEGFA-VEGFR2 Pathway RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases activate KTN1 RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHO GTPases Activate Formins RHO GTPases Activate Rhotekin and Rhophilins RHO GTPases Activate Rhotekin and Rhophilins Ovarian tumor domain proteases ERBB2 Regulates Cell Motility Neutrophil degranulation PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases SLIT2:ROBO1 increases RHOA activity
Drugs		Pentanal Balanol Analog 2 3-[(3-sec-butyl-4-hydroxybenzoyl)amino]azepan-4-yl 4-(2-hydroxy-5-methoxybenzoyl)benzoate Phosphonothreonine Balanol Analog 1 3,5-Diiodotyrosine Balanol Dexfosfoserine S,S-(2-Hydroxyethyl)Thiocysteine Hydroxyfasudil (2S)-1-(3H-Indol-3-yl)-3-{[5-(6-isoquinolinyl)-3-pyridinyl]oxy}-2-propanamine (2S)-1-{[5-(1H-Indazol-5-yl)-3-pyridinyl]oxy}-3-(7aH-indol-3-yl)-2-propanamine (1S)-2-(1H-INDOL-3-YL)-1-[({5-[(E)-2-PYRIDIN-4-YLVINYL]PYRIDIN-3-YL}OXY)METHYL]ETHYLAMINE (2S)-1-(6H-INDOL-3-YL)-3-{[5-(7H-PYRAZOLO[3,4-C]PYRIDIN-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE (1S)-1-(1H-INDOL-3-YLMETHYL)-2-(2-PYRIDIN-4-YL-[1,7]NAPHTYRIDIN-5-YLOXY)-EHYLAMINE N-[(1S)-2-AMINO-1-(2,4-DICHLOROBENZYL)ETHYL]-5-[2-(METHYLAMINO)PYRIMIDIN-4-YL]THIOPHENE-2-CARBOXAMIDE 3-(1H-indol-3-yl)-4-{1-[2-(1-methylpyrrolidin-2-yl)ethyl]-1H-indol-3-yl}-1H-pyrrole-2,5-dione (4R,2S)-5'-(4-(4-CHLOROBENZYLOXY)PYRROLIDIN-2-YLMETHANESULFONYL)ISOQUINOLINE N-METHYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE (S)-1-PHENYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE 6-{4-[4-(4-CHLOROPHENYL)PIPERIDIN-4-YL]PHENYL}-9H-PURINE (2R)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamine (2S)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamine 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE (2R)-2-(4-CHLOROPHENYL)-2-PHENYLETHANAMINE (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE H-89 5-(2-methylpiperazine-1-sulfonyl)isoquinoline N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE 2-[4-(3-METHYL-1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE 3-pyridin-4-yl-1H-indazole 5-benzyl-1,3-thiazol-2-amine 1-[4-(4-chlorophenyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine 1-[4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine 4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-aminium Fasudil Myristic acid A-674563 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.] PYRAZOLE Y-27632 Ellagic acid Fostamatinib	Guanosine-5'-Diphosphate
Diseases
GWAS			Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) Coronary artery disease ( 29212778 28714974) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Gut microbiota (functional units) ( 27694959) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908) Mood instability ( 31168069) Morning person ( 30696823) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		205 interacting genes: AANAT ABCA1 ACLY ADCY5 ADD1 ADD2 AKAP14 AKAP8L AKIP1 ANXA7 APC APOBEC3G ARFGEF3 ASIC1 ASIC3 ATF1 ATP2B1 AURKA AVPI1 BAD BCL2 BRAF CACNA1C CACNB2 CACNG2 CAD CALD1 CAMKK2 CCDC88A CCND1 CDK16 CDKN1A CETN1 CFTR CIITA CLDN3 CLTC CREB1 CREM CRK CSK CUL5 CYP3A4 DMTN DNAJC5 DOCK1 DRD1 DSP EEF2K EGFR ERBB3 ESR1 ETV1 FBXW11 FOS FXYD1 GABRB3 GABRR1 GAD1 GAD2 GFAP GJA5 GJB1 GLI1 GMFB GNA13 GNMT GP1BB GRIA1 GRIA4 GRK2 GSK3A GSK3B GUSB GYS1 HAND1 HAND2 HDAC1 HDAC8 HIF1A HMGCR HMGN1 HMGN2 HNF4A HNRNPD HSP90AA1 HSPA4 HSPD1 IFNAR1 IQGAP1 IRF2 ITCH ITGA2B ITGA4 ITPKA ITPKB ITPR1 ITPR2 KCNH2 KCNJ12 KCNQ1 KDELR1 KLF1 KLHL3 LCK LCP1 LIPE LRP1 MAP2 MAP3K3 MAPT MBP MC4R MEF2D MEP1B MGMT MIP NDRG1 NFKB1 NIN NOLC1 NOS1 NOXA1 NR3C1 NSFL1C NUP85 PDC PDE3A PDE3B PDE4B PDE4D PDPK1 PFKFB1 PFKFB2 PHKA1 PHOX2A PKIA PKIB PLIN1 PLN POU2F1 PPP1R10 PPP1R17 PPP1R1B PPP1R8 PPP1R9B PRKAR1A PRKAR1B PRKAR2B PSEN1 PSMD11 PTBP1 PTPN12 PTPN13 PTPN7 PTPRR RAF1 RANBP9 RAP1A RAP1B RAP1GAP RASGRF1 RASGRP3 RELA RGS10 RGS13 RGS14 RHOA RRAD RSBN1 RYR1 RYR2 SI SIK1 SIK3 SLC2A2 SLC4A4 SLC9A3R2 SNAP25 SNAPIN SNPH SPTBN1 SRC STK11 STMN1 STMN2 STUB1 SYN1 SYN2 TH THOP1 TNP1 TNP2 TPH1 TRIM55 TRIM63 TRIP10 UBE3A UHRF1 USP20 VASP VIM VTN WT1 YWHAZ	124 interacting genes: AGAP1 AGAP2 AKAP13 ANKS1B ARAP2 ARHGAP1 ARHGAP10 ARHGAP11A ARHGAP11B ARHGAP19 ARHGAP20 ARHGAP21 ARHGAP22 ARHGAP23 ARHGAP26 ARHGAP29 ARHGAP31 ARHGAP32 ARHGAP40 ARHGAP5 ARHGAP8 ARHGDIA ARHGDIB ARHGDIG ARHGEF1 ARHGEF10 ARHGEF11 ARHGEF12 ARHGEF15 ARHGEF17 ARHGEF18 ARHGEF19 ARHGEF2 ARHGEF25 ARHGEF28 ARHGEF3 ARHGEF4 ARHGEF5 ARNTL BCR BIRC2 CAV1 CIT CLOCK CNKSR1 CNTNAP1 DAAM1 DCUN1D1 DEF6 DGKQ DIAPH1 DIAPH3 DLC1 DOCK7 DVL2 FLNA FMN2 GMIP HSPA1A ICMT IKBKG IKZF3 ITPR1 KCNA2 KCTD13 KTN1 LRP2 MCF2 MCF2L MPRIP MYO9A NET1 NGEF NOTCH1 OPHN1 OTUB1 PDE6D PITPNM1 PKN1 PKN2 PLCG1 PLD1 PLEKHG2 PLEKHG4 PLEKHG6 PPP1R12A PREX1 PREX2 PRKACA PRKCA PRKCZ PTPRF RABAC1 RACK1 RAP1GDS1 RASGRF1 RASGRF2 RASSF1 RHPN1 RHPN2 RIPK4 RIPOR2 RIPOR3 ROCK1 RPN2 RTKN SH3BP1 SLC13A1 SMAD2 SMURF1 SMURF2 SPRED2 SRGAP1 STARD8 TGFBR1 TGM2 TIAM1 TNFAIP1 TRIO TRIP6 TRPC1 VAV1 VAV2 VAV3
Entrez ID		5566	387
HPRD ID		03382	01323
Ensembl ID		ENSG00000072062	ENSG00000067560
Uniprot IDs		A0A024R7J0 A8K8B9 P17612	A0A024R324 B4DKN9 C9JRM1 C9JX21 P61586 Q9BVT0
PDB IDs		2GU8 3AGL 3AGM 3AMA 3AMB 3L9L 3L9M 3L9N 3MVJ 3NX8 3OOG 3OVV 3OWP 3OXT 3P0M 3POO 3VQH 4AE6 4AE9 4UJ1 4UJ2 4UJ9 4UJA 4UJB 4WB5 4WB6 4WB7 4WB8 5BX6 5BX7 5IZF 5IZJ 5J5X 5N23 5UZK 6BYR 6BYS 6C0U 6FRX 6NO7 6QJ7	1A2B 1CC0 1CXZ 1DPF 1FTN 1KMQ 1LB1 1OW3 1S1C 1TX4 1X86 1XCG 2RGN 3KZ1 3LW8 3LWN 3LXR 3MSX 3T06 4D0N 4XH9 4XOI 4XSG 4XSH 5A0F 5BWM 5C2K 5C4M 5EZ6 5FR1 5FR2 5HPY 5IRC 5JCP 5JHG 5JHH 5M6X 5M70 5ZHX 6BC0 6BCA 6BCB 6KX2 6KX3 6R3V
Enriched GO Terms of Interacting Partners?
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