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SMPD4 and EXOSC4
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
SMPD4
EXOSC4
Description
sphingomyelin phosphodiesterase 4
exosome component 4
Image
No pdb structure
GO Annotations
Cellular Component
Golgi Membrane
Nuclear Envelope
Nuclear Outer Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Trans-Golgi Network
Integral Component Of Membrane
Sarcolemma
Nuclear Exosome (RNase Complex)
Cytoplasmic Exosome (RNase Complex)
Exosome (RNase Complex)
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Transcriptionally Active Chromatin
Intracellular Membrane-bounded Organelle
Molecular Function
Sphingomyelin Phosphodiesterase Activity
Metal Ion Binding
Sphingomyelin Phosphodiesterase D Activity
3'-5'-exoribonuclease Activity
Exoribonuclease Activity
Protein Binding
MRNA 3'-UTR AU-rich Region Binding
Biological Process
Sphingomyelin Catabolic Process
Glycosphingolipid Metabolic Process
Endoplasmic Reticulum Organization
Glycerophospholipid Catabolic Process
Ceramide Biosynthetic Process
Cellular Response To Tumor Necrosis Factor
Maturation Of 5.8S RRNA
Nuclear-transcribed MRNA Catabolic Process
RRNA Processing
RRNA Catabolic Process
Positive Regulation Of Cell Growth
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
U4 SnRNA 3'-end Processing
Regulation Of MRNA Stability
Exonucleolytic Catabolism Of Deadenylated MRNA
DNA Deamination
Defense Response To Virus
Nuclear MRNA Surveillance
Histone MRNA Catabolic Process
Polyadenylation-dependent SnoRNA 3'-end Processing
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways
Glycosphingolipid metabolism
ATF4 activates genes in response to endoplasmic reticulum stress
mRNA decay by 3' to 5' exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Phosphatidyl serine
Diseases
GWAS
Asthma (
31959851
)
Bipolar disorder (
31043756
)
Bipolar I disorder (
31043756
)
Interacting Genes
2 interacting genes:
ERBB2
EXOSC4
33 interacting genes:
AKR1A1
DIS3
DXO
EEF1A1
EXOSC1
EXOSC10
EXOSC2
EXOSC3
EXOSC6
EXOSC7
EXOSC8
EXOSC9
FAHD1
GADD45GIP1
GTF2IRD1
HBS1L
HNRNPD
LNX1
LRRC8D
MPZL1
MTREX
NEK1
PALS2
POLE2
PPARA
PTEN
SDCBP
SKIV2L
SMPD4
TSEN15
UPF1
UPF2
UPF3B
Entrez ID
55627
54512
HPRD ID
13374
16221
Ensembl ID
ENSG00000136699
ENSG00000178896
Uniprot IDs
Q9NXE4
Q9NPD3
PDB IDs
2NN6
6D6Q
6D6R
6H25
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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