SMPD4 and EXOSC4

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SMPD4	EXOSC4
Description		sphingomyelin phosphodiesterase 4	exosome component 4
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nuclear Envelope Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Integral Component Of Membrane Sarcolemma	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin Intracellular Membrane-bounded Organelle
	Molecular Function	Sphingomyelin Phosphodiesterase Activity Metal Ion Binding Sphingomyelin Phosphodiesterase D Activity	3'-5'-exoribonuclease Activity Exoribonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding
	Biological Process	Sphingomyelin Catabolic Process Glycosphingolipid Metabolic Process Endoplasmic Reticulum Organization Glycerophospholipid Catabolic Process Ceramide Biosynthetic Process Cellular Response To Tumor Necrosis Factor	Maturation Of 5.8S RRNA Nuclear-transcribed MRNA Catabolic Process RRNA Processing RRNA Catabolic Process Positive Regulation Of Cell Growth Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Histone MRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		Glycosphingolipid metabolism	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs		Phosphatidyl serine
Diseases
GWAS			Asthma ( 31959851) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756)
Interacting Genes		2 interacting genes: ERBB2 EXOSC4	33 interacting genes: AKR1A1 DIS3 DXO EEF1A1 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FAHD1 GADD45GIP1 GTF2IRD1 HBS1L HNRNPD LNX1 LRRC8D MPZL1 MTREX NEK1 PALS2 POLE2 PPARA PTEN SDCBP SKIV2L SMPD4 TSEN15 UPF1 UPF2 UPF3B
Entrez ID		55627	54512
HPRD ID		13374	16221
Ensembl ID		ENSG00000136699	ENSG00000178896
Uniprot IDs		Q9NXE4	Q9NPD3
PDB IDs			2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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