EXOSC4 and AKR1A1

Data Source:
HPRD (two hybrid)

		EXOSC4	AKR1A1
Description		exosome component 4	aldo-keto reductase family 1 member A1
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin Intracellular Membrane-bounded Organelle	Extracellular Space Cytosol Apical Plasma Membrane Synapse Extracellular Exosome
	Molecular Function	3'-5'-exoribonuclease Activity Exoribonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding	Alditol:NADP+ 1-oxidoreductase Activity Aldo-keto Reductase (NADP) Activity Retinol Dehydrogenase Activity Protein Binding Electron Transfer Activity Allyl-alcohol Dehydrogenase Activity L-glucuronate Reductase Activity Glucuronolactone Reductase Activity
	Biological Process	Maturation Of 5.8S RRNA Nuclear-transcribed MRNA Catabolic Process RRNA Processing RRNA Catabolic Process Positive Regulation Of Cell Growth Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Histone MRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Glucose Metabolic Process Cellular Aldehyde Metabolic Process Glucuronate Catabolic Process To Xylulose 5-phosphate L-ascorbic Acid Biosynthetic Process Electron Transport Chain D-glucuronate Catabolic Process Daunorubicin Metabolic Process Doxorubicin Metabolic Process Aldehyde Catabolic Process Cellular Detoxification Of Aldehyde Glutathione Derivative Biosynthetic Process
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol	Glutathione conjugation Formation of xylulose-5-phosphate
Drugs			Tolrestat Nicotinamide adenine dinucleotide phosphate Copper
Diseases
GWAS		Asthma ( 31959851) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756)	Blood protein levels ( 30072576 29875488) Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 31152163) High light scatter reticulocyte count ( 32888494 27863252) Pulse pressure ( 30224653 30578418) Reticulocyte fraction of red cells ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		33 interacting genes: AKR1A1 DIS3 DXO EEF1A1 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FAHD1 GADD45GIP1 GTF2IRD1 HBS1L HNRNPD LNX1 LRRC8D MPZL1 MTREX NEK1 PALS2 POLE2 PPARA PTEN SDCBP SKIV2L SMPD4 TSEN15 UPF1 UPF2 UPF3B	4 interacting genes: EXOSC4 HTR6 TERF1 TERF2IP
Entrez ID		54512	10327
HPRD ID		16221	00069
Ensembl ID		ENSG00000178896	ENSG00000117448
Uniprot IDs		Q9NPD3	P14550 V9HWI0
PDB IDs		2NN6 6D6Q 6D6R 6H25	2ALR
Enriched GO Terms of Interacting Partners?
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