PI4K2A and ECSIT

Data Source:
BioGRID (two hybrid)

		PI4K2A	ECSIT
Description		phosphatidylinositol 4-kinase type 2 alpha	ECSIT signaling integrator
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Lysosomal Membrane Endosome Trans-Golgi Network Cytosol Plasma Membrane Integral Component Of Plasma Membrane Membrane Dendrite BLOC-1 Complex Intrinsic Component Of Membrane Cytoplasmic Vesicle Growing Cell Tip Presynaptic Membrane Neuron Projection Neuronal Cell Body Perikaryon Membrane Raft	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol
	Molecular Function	Magnesium Ion Binding 1-phosphatidylinositol 4-kinase Activity Protein Binding ATP Binding AP-3 Adaptor Complex Binding	Protein Binding
	Biological Process	Phosphatidylinositol Biosynthetic Process Golgi Organization Endosome Organization Phosphatidylinositol Phosphorylation	Mitochondrial Respiratory Chain Complex I Assembly Innate Immune Response Regulation Of Oxidoreductase Activity Regulation Of Protein Complex Stability
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane	MyD88:MAL(TIRAP) cascade initiated on plasma membrane Complex I biogenesis TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane
Drugs
Diseases
GWAS			Presence of antiphospholipid antibodies ( 27098658)
Interacting Genes		6 interacting genes: APP CD63 ECSIT HRAS NOS3 RAD23A	52 interacting genes: A2M AP1M2 APOE APP BFSP2 BLMH C1orf109 CDC37 CEP55 CTNNA3 CYP2C18 CYP2C8 CYP2C9 DNAJB1 DTX2 ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 GCDH GEM IFIT3 IFIT5 IMMT LONP1 LOXL4 MAGEB2 MAST1 MKRN3 NFKB1 NXF1 PAXIP1 PI4K2A PRDX2 PSEN1 RAB3A RAD23A RELA RHEB RNF32 SETDB1 SMAD1 SMAD4 SMURF1 STAMBPL1 STRN4 TARS3 TRAF6 TRIM59 TSSK3
Entrez ID		55361	51295
HPRD ID		11431	12225
Ensembl ID		ENSG00000155252	ENSG00000130159
Uniprot IDs		Q9BTU6	Q9BQ95
PDB IDs		4HND 4HNE 4PLA 4YC4 5EUT 5I0N
Enriched GO Terms of Interacting Partners?
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