PPP3R2 and PTPN12

Data Source:
BioGRID (two hybrid)

		PPP3R2	PTPN12
Description		protein phosphatase 3 regulatory subunit B, beta	protein tyrosine phosphatase non-receptor type 12
Image		No pdb structure
GO Annotations	Cellular Component		Podosome Nucleus Nucleoplasm Cytoplasm Cytosol Focal Adhesion Cell Projection
	Molecular Function	Calcium Ion Binding Protein Binding Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding SH3 Domain Binding
	Biological Process	Regulation Of Phosphoprotein Phosphatase Activity	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation ERBB2 Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Tissue Regeneration Cellular Response To Cytokine Stimulus Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of ERBB Signaling Pathway Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways			SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling EGFR downregulation Signaling by PDGF Downregulation of ERBB2 signaling Interleukin-37 signaling Constitutive Signaling by Overexpressed ERBB2
Drugs		Cyclosporine Voclosporin	Tiludronic acid
Diseases
GWAS			Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31015462) Lymphocyte counts ( 32888494) Monocyte count ( 32888494)
Interacting Genes		19 interacting genes: APC AURKA BUB1 CCND1 CD14 DLC1 DYNLL1 FBXW7 KRT34 MLH3 MSH2 PDGFRL PPP3CA PTPN12 PTPRJ RAB32 SMAD4 TBC1D10C TFCP2	57 interacting genes: AATK ABL1 ANP32B APP BAG6 BCAR1 CCDC180 CGA CSH1 CSH2 CSK EFS EGFR ERBB3 ERBB4 FANCC FGFR2 FGFR4 FLT3 FRAT2 GRB2 IFT20 IGF1R INSR JAK2 KDR LMTK2 LPXN MYCBP2 NEDD9 PPP3R2 PRKACA PRKCA PSG9 PSTPIP1 PSTPIP2 PTK2 PTK2B PTK7 PXN RBM19 ROR2 SFRP4 SHC1 SMAD1 SMAD5 SORBS2 STX16 STX17 TENM1 TEX10 TGFB1I1 THAP2 UTRN WAS ZFP2 ZNF510
Entrez ID		5535	5782
HPRD ID		10164	02513
Ensembl ID		ENSG00000188386	ENSG00000127947
Uniprot IDs		Q96LZ3	B4E105 Q05209
PDB IDs			5HDE 5J8R 5O2P
Enriched GO Terms of Interacting Partners?
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