PPP3R1 and NFATC1

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		PPP3R1	NFATC1
Description		protein phosphatase 3 regulatory subunit B, alpha	nuclear factor of activated T cells 1
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Cytosol Calcineurin Complex Sarcolemma	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Nuclear Body
	Molecular Function	Calcium-dependent Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity Cyclosporin A Binding Phosphatase Binding Protein Domain Specific Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding RNA Polymerase II Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding FK506 Binding Transcription Factor Binding Mitogen-activated Protein Kinase P38 Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Dephosphorylation Wnt Signaling Pathway, Calcium Modulating Pathway Calcineurin-NFAT Signaling Cascade Fc-epsilon Receptor Signaling Pathway Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	Cytokine Production Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Regulation Of Transcription By RNA Polymerase II Wnt Signaling Pathway, Calcium Modulating Pathway Negative Regulation Of Wnt Signaling Pathway Calcineurin-NFAT Signaling Cascade Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation
Pathways		Activation of BAD and translocation to mitochondria DARPP-32 events Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation	Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation
Drugs		Myristic acid Voclosporin	Pseudoephedrine
Diseases
GWAS		General cognitive ability ( 29844566) Height ( 25282103) Intelligence (MTAG) ( 29326435) Schizophrenia ( 30285260) Urinary potassium excretion ( 31409800)	Blood urea nitrogen levels ( 31152163 29403010) Body size at age 10 ( 32376654) Cerebrospinal P-tau181p levels ( 28247064) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic kidney disease ( 31152163 29124443) Creatinine levels ( 31015462 29124443 29403010) Crohn's disease ( 26192919) Estimated glomerular filtration rate ( 31152163 31015462 31451708 29779033 29124443 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Feeling hurt ( 29500382) Femoral neck bone mineral density ( 32239398) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate (creatinine) ( 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Hyperuricemia ( 29124443) Inflammatory bowel disease ( 26192919) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 32888494 27863252) Medication use (drugs affecting bone structure and mineralization) ( 31015401) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494) Normal facial asymmetry (angle of surface orientation score) ( 30631343) Refractive error ( 32231278) Serum creatinine levels ( 29779033) Working memory ( 31598132)
Interacting Genes		10 interacting genes: CABP1 CABP2 CABP5 CHRNA6 MAP3K5 NAP1L2 NFATC1 NFATC2 PPP3CA PPP3CC	16 interacting genes: EGR1 EGR2 EP300 HDAC5 KAT2B KPNB1 MAPK14 PARP1 PIAS1 PIM1 PPP3R1 PRKCA RACK1 SPI1 TUBA1A YWHAQ
Entrez ID		5534	4772
HPRD ID		03195	02729
Ensembl ID		ENSG00000221823	ENSG00000131196
Uniprot IDs		P63098	A8K9C6 B4DER8 F5H4S8 O95644
PDB IDs		1AUI 1M63 1MF8 2P6B 3LL8 4F0Z 4OR9 4ORA 4ORC 5SVE 6NUC 6NUF 6NUU	1A66 1NFA 5SVE
Enriched GO Terms of Interacting Partners?
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