TMEM140 and SCN3B

Data Source:
BioGRID (two hybrid)

		TMEM140	SCN3B
Description		transmembrane protein 140	sodium voltage-gated channel beta subunit 3
Image		No pdb structure
GO Annotations	Cellular Component	Integral Component Of Membrane	Voltage-gated Sodium Channel Complex Plasma Membrane Integral Component Of Membrane Z Disc
	Molecular Function	Protein Binding	Voltage-gated Ion Channel Activity Protein Binding Sodium Channel Regulator Activity Sodium Channel Inhibitor Activity Ion Channel Binding Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential
	Biological Process		Sodium Ion Transport Nervous System Development Positive Regulation Of Heart Rate Positive Regulation Of Sodium Ion Transport Sensory Perception Of Pain Sodium Ion Transmembrane Transport Membrane Depolarization Cardiac Muscle Contraction Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Protein Localization To Plasma Membrane Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Depolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential SA Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways			Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs			Ranolazine Valproic acid Oxcarbazepine Cocaine Zonisamide Brivaracetam Dichlorobenzyl alcohol Fish oil
Diseases			Brugada syndrome (BRS)
GWAS			Chronic lymphocytic leukemia ( 28165464 24292274 23770605) Response to citalopram or escitalopram in depression ( 27622933)
Interacting Genes		50 interacting genes: APH1A AQP6 ASGR2 CD22 CD53 CD79A CGRRF1 CLDN5 CLDN7 CLEC17A CLRN1 CREB3 EBP FAM209A FAM210B FCER1G FNDC9 GOLM1 GPR152 GPR42 HHLA2 HSD17B13 IFNGR2 KCNJ8 KRTAP10-8 LMNA LY6E MFF MGST3 MILR1 MS4A3 MSMO1 PDZK1IP1 PSCA RMDN3 SCN3B SHISAL1 SIT1 SLC39A9 SPACA1 STOM SYNE4 TEX29 TMEM182 TMEM205 TMEM207 TMEM9 TMX2 TSPAN12 TSPO2	105 interacting genes: ADIPOQ AGPAT4 AGPAT5 ANKRD46 AQP10 ARV1 ATP13A1 ATP6V0C BNIP1 BNIP3 BRICD5 CLCA4 CTXN3 CYP4F2 DEFB103A DEFB103B DERL1 DGAT2L6 ERG28 FAM241B FAM3C FIS1 FKBP8 FXYD3 GIMAP1 GIMAP5 GPR151 GPR61 IER3IP1 INSIG2 ISM2 ITGAM LEMD1 LEPROTL1 LPAR3 MAL2 MARCHF2 MFSD5 MGST3 MS4A13 NFASC NINJ2 ORMDL1 ORMDL2 PLBD2 PLP2 PLPPR2 PMP22 RHD RNF8 RUSF1 SACM1L SCD SEC22A SERP2 SFT2D1 SFXN1 SFXN3 SLC2A5 SLC30A3 SLC30A8 SLC35A4 SLC35E4 SLC38A1 SLC38A7 SLC7A1 SMCO4 SMIM1 STRIT1 STX3 STX6 STX8 THSD7A TIMM23 TM6SF2 TMBIM6 TMEM120A TMEM120B TMEM128 TMEM140 TMEM14A TMEM14B TMEM208 TMEM239 TMEM243 TMEM42 TMEM50B TMEM60 TMEM65 TMEM86A TMPPE TPRG1 TRARG1 TSPAN2 TVP23B UBIAD1 USE1 VAMP1 VAMP2 VAMP3 VAPA VAPB YIF1A YIPF4 ZFPL1
Entrez ID		55281	55800
HPRD ID		07723	10497
Ensembl ID		ENSG00000146859	ENSG00000166257
Uniprot IDs		Q9NV12	A0A024R3H7 Q9NY72
PDB IDs			4L1D
Enriched GO Terms of Interacting Partners?
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