FANCL and HDHD3

Data Source:
BioGRID (two hybrid)

		FANCL	HDHD3
Description		FA complementation group L	haloacid dehalogenase like hydrolase domain containing 3
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Nuclear Body Intracellular Membrane-bounded Organelle Fanconi Anaemia Nuclear Complex	Nucleolus Intracellular Membrane-bounded Organelle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Hydrolase Activity
	Biological Process	DNA Repair Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Gamete Generation Interstrand Cross-link Repair Regulation Of Cell Population Proliferation
Pathways		Fanconi Anemia Pathway
Drugs
Diseases		Fanconi anemia
GWAS		Adult body size ( 32376654) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 31453325 20935630) Body mass index variance ( 31453325) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Childhood absence epilepsy ( 30531953) Chronotype ( 30696823) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Epilepsy ( 25087078 30531953) Feeling miserable ( 29500382) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Generalized epilepsy ( 30531953) HDL cholesterol levels ( 32203549) Hirschsprung disease ( 27702942) Initial pursuit acceleration ( 29064472) Irritable mood ( 29500382) Obesity ( 23563607) Pre-treatment viral load in HIV-1 infection ( 31219150) Response to selective serotonin reuptake inhibitors and depression ( 27622933) Schizophrenia ( 25056061 29483656) Smoking status (ever vs never smokers) ( 30643258) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Tea consumption ( 31046077) Triglyceride levels ( 32203549) Type 2 diabetes ( 30718926) Waist circumference ( 25673412) Waist-hip ratio ( 25673412)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Metabolite levels ( 23823483)
Interacting Genes		48 interacting genes: ACVR1 ANTKMT BMPR1B C19orf54 CADPS CERCAM CHCHD3 CTBP1 CTDSP1 CYB5R2 DDAH2 DOCK8 EIF4ENIF1 FAAP100 FANCB FANCD2 FANCF FANCI GATA1 GGN GRN HDHD3 HES1 HOXD4 ID2 IHO1 IKZF3 KIFC3 KRTAP11-1 KRTAP13-2 KRTAP19-6 LZTS2 METTL15 MORN3 PCNA RBM45 RIMBP3 RNF11 SCNM1 SNF8 SSX2IP TFCP2 TGFBR1 UBE2T UBE2W UFSP1 YPEL3 ZNF581	13 interacting genes: ATG9A CSTF2 CYSRT1 FANCL FOXH1 KLHL38 PLSCR4 POU4F2 PROP1 SMYD1 TLE5 TRIP13 VAC14
Entrez ID		55120	81932
HPRD ID		06997	13641
Ensembl ID		ENSG00000115392	ENSG00000119431
Uniprot IDs		Q9NW38	Q9BSH5
PDB IDs		3ZQS 4CCG	3K1Z
Enriched GO Terms of Interacting Partners?
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