FANCL and FANCI

Data Source:
BioGRID (enzymatic study, enzymatic study, enzymatic study, unspecified method, enzymatic study)

		FANCL	FANCI
Description		FA complementation group L	FA complementation group I
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Nuclear Body Intracellular Membrane-bounded Organelle Fanconi Anaemia Nuclear Complex	Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	DNA Binding Protein Binding DNA Polymerase Binding
	Biological Process	DNA Repair Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Gamete Generation Interstrand Cross-link Repair Regulation Of Cell Population Proliferation	Cell Cycle Positive Regulation Of Protein Ubiquitination Interstrand Cross-link Repair
Pathways		Fanconi Anemia Pathway	Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes
Drugs
Diseases		Fanconi anemia	Fanconi anemia
GWAS		Adult body size ( 32376654) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 31453325 20935630) Body mass index variance ( 31453325) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Childhood absence epilepsy ( 30531953) Chronotype ( 30696823) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Epilepsy ( 25087078 30531953) Feeling miserable ( 29500382) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Generalized epilepsy ( 30531953) HDL cholesterol levels ( 32203549) Hirschsprung disease ( 27702942) Initial pursuit acceleration ( 29064472) Irritable mood ( 29500382) Obesity ( 23563607) Pre-treatment viral load in HIV-1 infection ( 31219150) Response to selective serotonin reuptake inhibitors and depression ( 27622933) Schizophrenia ( 25056061 29483656) Smoking status (ever vs never smokers) ( 30643258) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Tea consumption ( 31046077) Triglyceride levels ( 32203549) Type 2 diabetes ( 30718926) Waist circumference ( 25673412) Waist-hip ratio ( 25673412)	Height ( 25282103) Menopause (age at onset) ( 26414677) Red cell distribution width ( 32888494) Serum immune biomarker levels ( 32066700)
Interacting Genes		48 interacting genes: ACVR1 ANTKMT BMPR1B C19orf54 CADPS CERCAM CHCHD3 CTBP1 CTDSP1 CYB5R2 DDAH2 DOCK8 EIF4ENIF1 FAAP100 FANCB FANCD2 FANCF FANCI GATA1 GGN GRN HDHD3 HES1 HOXD4 ID2 IHO1 IKZF3 KIFC3 KRTAP11-1 KRTAP13-2 KRTAP19-6 LZTS2 METTL15 MORN3 PCNA RBM45 RIMBP3 RNF11 SCNM1 SNF8 SSX2IP TFCP2 TGFBR1 UBE2T UBE2W UFSP1 YPEL3 ZNF581	13 interacting genes: AKT1 APP ATR BRCA2 FANCD2 FANCL MTDH MTNR1B PIAS1 RAD51 UBL5 USP1 WDR48
Entrez ID		55120	55215
HPRD ID		06997	13339
Ensembl ID		ENSG00000115392	ENSG00000140525
Uniprot IDs		Q9NW38	B3KNW8 Q9NVI1
PDB IDs		3ZQS 4CCG	6VAA 6VAD 6VAE 6VAF
Enriched GO Terms of Interacting Partners?
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