AVP and AVPR1A

Data Source:
HPRD (in vivo)

		AVP	AVPR1A
Description		arginine vasopressin	arginine vasopressin receptor 1A
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Secretory Granule Dendrite Clathrin-coated Vesicle Membrane	Endosome Plasma Membrane Integral Component Of Plasma Membrane Endocytic Vesicle
	Molecular Function	Protein Kinase Activity Signaling Receptor Binding Neuropeptide Hormone Activity Neurohypophyseal Hormone Activity Protein Binding V1A Vasopressin Receptor Binding V1B Vasopressin Receptor Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process	G Protein-coupled Receptor Activity Vasopressin Receptor Activity Protein Kinase C Binding Protein Binding Peptide Hormone Binding V1A Vasopressin Receptor Binding Peptide Binding
	Biological Process	Maternal Aggressive Behavior Positive Regulation Of Systemic Arterial Blood Pressure Renal Water Homeostasis Generation Of Precursor Metabolites And Energy Protein Phosphorylation Water Transport Apoptotic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Negative Regulation Of Female Receptivity Grooming Behavior Locomotory Behavior Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Glutamate Secretion Positive Regulation Of Cell Growth Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Cellular PH Reduction Positive Regulation Of Peptidyl-serine Phosphorylation Response To Testosterone Response To Nicotine Social Behavior Regulation Of Renal Sodium Excretion Vasoconstriction Hyperosmotic Salinity Response Maternal Behavior Negative Regulation Of Apoptotic Process Penile Erection Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Ethanol Positive Regulation Of Vasoconstriction Negative Regulation Of Transmission Of Nerve Impulse Membrane Organization ERK1 And ERK2 Cascade Protein Kinase C Signaling Negative Regulation Of Release Of Cytochrome C From Mitochondria	Regulation Of Systemic Arterial Blood Pressure By Vasopressin Maternal Aggressive Behavior Positive Regulation Of Systemic Arterial Blood Pressure Generation Of Precursor Metabolites And Energy G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Female Receptivity Grooming Behavior Blood Circulation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Heart Rate Positive Regulation Of Glutamate Secretion Myotube Differentiation Calcium-mediated Signaling Telencephalon Development Positive Regulation Of Cell Growth Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Cellular PH Reduction Social Behavior Positive Regulation Of Renal Sodium Excretion Cellular Response To Water Deprivation Maternal Behavior Sperm Ejaculation Penile Erection Positive Regulation Of Vasoconstriction Response To Corticosterone Negative Regulation Of Transmission Of Nerve Impulse Transport Across Blood-brain Barrier
Pathways		BMAL1:CLOCK,NPAS2 activates circadian gene expression Vasopressin-like receptors G alpha (q) signalling events G alpha (s) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) Transport of organic anions Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) ADORA2B mediated anti-inflammatory cytokines production	Vasopressin-like receptors G alpha (q) signalling events Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)
Drugs			Desmopressin Vasopressin Felypressin Conivaptan Terlipressin PH-284 Tolvaptan Atosiban Relcovaptan Lypressin
Diseases		Neurohypophyseal diabetes insipidus (NPDI); Central Diabetes Insipidus
GWAS			Chronotype ( 30696823) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hippocampal volume ( 29860282) Morning person ( 30696823) Type 2 diabetes ( 31049640)
Interacting Genes		9 interacting genes: AVPR1A AVPR1B AVPR2 CRYAB DLX2 KMT2A OXTR PRKAB2 TXNDC17	3 interacting genes: AVP GRK5 PRKCA
Entrez ID		551	552
HPRD ID		01891	02894
Ensembl ID		ENSG00000101200	ENSG00000166148
Uniprot IDs		P01185 X5DQP6	P37288 X5D2B0
PDB IDs			1YTV
Enriched GO Terms of Interacting Partners?
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