AVPR1A and GRK5

Data Source:
HPRD (in vivo, in vitro)

		AVPR1A	GRK5
Description		arginine vasopressin receptor 1A	G protein-coupled receptor kinase 5
Image
GO Annotations	Cellular Component	Endosome Plasma Membrane Integral Component Of Plasma Membrane Endocytic Vesicle	Cytoplasm Cytosol Plasma Membrane Nuclear Speck Nuclear Membrane
	Molecular Function	G Protein-coupled Receptor Activity Vasopressin Receptor Activity Protein Kinase C Binding Protein Binding Peptide Hormone Binding V1A Vasopressin Receptor Binding Peptide Binding	Protein Serine/threonine Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Phospholipid Binding Beta-adrenergic Receptor Kinase Activity
	Biological Process	Regulation Of Systemic Arterial Blood Pressure By Vasopressin Maternal Aggressive Behavior Positive Regulation Of Systemic Arterial Blood Pressure Generation Of Precursor Metabolites And Energy G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Female Receptivity Grooming Behavior Blood Circulation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Heart Rate Positive Regulation Of Glutamate Secretion Myotube Differentiation Calcium-mediated Signaling Telencephalon Development Positive Regulation Of Cell Growth Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Cellular PH Reduction Social Behavior Positive Regulation Of Renal Sodium Excretion Cellular Response To Water Deprivation Maternal Behavior Sperm Ejaculation Penile Erection Positive Regulation Of Vasoconstriction Response To Corticosterone Negative Regulation Of Transmission Of Nerve Impulse Transport Across Blood-brain Barrier	Apoptotic Process G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Wnt Signaling Pathway Negative Regulation Of Apoptotic Process Protein Autophosphorylation Regulation Of Cell Cycle
Pathways		Vasopressin-like receptors G alpha (q) signalling events Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)	G alpha (q) signalling events G alpha (s) signalling events
Drugs		Desmopressin Vasopressin Felypressin Conivaptan Terlipressin PH-284 Tolvaptan Atosiban Relcovaptan Lypressin
Diseases
GWAS		Chronotype ( 30696823) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hippocampal volume ( 29860282) Morning person ( 30696823) Type 2 diabetes ( 31049640)	Coronary artery aneurysm in Kawasaki disease ( 27171184) Early onset periodontitis x smoking status interaction ( 31537151) Height ( 28552196) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 32888494 27863252) Methadone dose in opioid dependence ( 30060048) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) Risky sexual behaviors in alcohol dependence ( 28990359) Thrombin-induced platelet aggregation ( 32649856) Type 2 diabetes ( 22961080) Venous thromboembolism ( 31420334 31676865)
Interacting Genes		3 interacting genes: AVP GRK5 PRKCA	19 interacting genes: ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CABP1 CALM1 CAV1 CHRM2 DLGAP2 GIT1 RCVRN RHO SNCA SNCB SNCG TACR1 TBXA2R
Entrez ID		552	2869
HPRD ID		02894	02926
Ensembl ID		ENSG00000166148	ENSG00000198873
Uniprot IDs		P37288 X5D2B0	P34947
PDB IDs		1YTV	4TNB 4TND
Enriched GO Terms of Interacting Partners?
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