SSH3 and LIMK1

Data Source:
HPRD (in vitro)

		SSH3	LIMK1
Description		slingshot protein phosphatase 3	LIM domain kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton	Nucleus Cytoplasm Cytosol Cytoskeleton Nuclear Speck Lamellipodium Neuron Projection
	Molecular Function	Actin Binding Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Heat Shock Protein Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Actin Cytoskeleton Organization Negative Regulation Of Actin Filament Polymerization Peptidyl-tyrosine Dephosphorylation	Protein Phosphorylation Signal Transduction Rho Protein Signal Transduction Nervous System Development Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Bundle Assembly Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Axon Extension Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Stress Fiber Assembly
Pathways			Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling Sema3A PAK dependent Axon repulsion Sema3A PAK dependent Axon repulsion Sema4D induced cell migration and growth-cone collapse RHO GTPases Activate ROCKs RHO GTPases activate PAKs
Drugs			Dabrafenib Fostamatinib
Diseases
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body size at age 10 ( 32376654) HDL cholesterol levels ( 32203549)	Pulse pressure ( 30224653) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		6 interacting genes: ACTB APP CFL1 LIMK1 MTDH NCK2	30 interacting genes: ABCA1 APP ARRB1 ARRB2 BMPR2 C22orf15 CDC42BPA CDKN1C CFL1 CFL2 FBXO7 H1-1 LATS1 LIMK2 MAPK14 MAPKAPK2 MBP MFHAS1 NRG1 PAK1 PAK2 PAK4 PAK6 PXN RLIM ROCK1 SRPK1 SSH3 WASHC1 YWHAZ
Entrez ID		54961	3984
HPRD ID		09488	03210
Ensembl ID		ENSG00000172830	ENSG00000106683
Uniprot IDs		A0A024R5J4 Q8TE77	P53667
PDB IDs			3S95 5HVJ 5HVK 5L6W 5NXC 6WLY
Enriched GO Terms of Interacting Partners?
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