LIMK1 and SSH3

Data Source:
HPRD (in vitro)

		LIMK1	SSH3
Description		LIM domain kinase 1	slingshot protein phosphatase 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Nuclear Speck Lamellipodium Neuron Projection	Nucleus Cytoplasm Cytoskeleton
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Heat Shock Protein Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Actin Binding Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Protein Phosphorylation Signal Transduction Rho Protein Signal Transduction Nervous System Development Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Bundle Assembly Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Axon Extension Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Stress Fiber Assembly	Actin Cytoskeleton Organization Negative Regulation Of Actin Filament Polymerization Peptidyl-tyrosine Dephosphorylation
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling Sema3A PAK dependent Axon repulsion Sema3A PAK dependent Axon repulsion Sema4D induced cell migration and growth-cone collapse RHO GTPases Activate ROCKs RHO GTPases activate PAKs
Drugs		Dabrafenib Fostamatinib
Diseases
GWAS		Pulse pressure ( 30224653) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Youthful appearance (self-reported) ( 32339537)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body size at age 10 ( 32376654) HDL cholesterol levels ( 32203549)
Interacting Genes		30 interacting genes: ABCA1 APP ARRB1 ARRB2 BMPR2 C22orf15 CDC42BPA CDKN1C CFL1 CFL2 FBXO7 H1-1 LATS1 LIMK2 MAPK14 MAPKAPK2 MBP MFHAS1 NRG1 PAK1 PAK2 PAK4 PAK6 PXN RLIM ROCK1 SRPK1 SSH3 WASHC1 YWHAZ	6 interacting genes: ACTB APP CFL1 LIMK1 MTDH NCK2
Entrez ID		3984	54961
HPRD ID		03210	09488
Ensembl ID		ENSG00000106683	ENSG00000172830
Uniprot IDs		P53667	A0A024R5J4 Q8TE77
PDB IDs		3S95 5HVJ 5HVK 5L6W 5NXC 6WLY
Enriched GO Terms of Interacting Partners?
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