PPL and LARP1

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)

		PPL	LARP1
Description		periplakin	La ribonucleoprotein 1, translational regulator
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GO Annotations	Cellular Component	Cornified Envelope Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Membrane Desmosome Extracellular Exosome	Cytoplasm Polysome Cytoplasmic Stress Granule Membrane TORC1 Complex Polysomal Ribosome
	Molecular Function	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cadherin Binding	RNA Cap Binding RNA 7-methylguanosine Cap Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Eukaryotic Initiation Factor 4E Binding Translation Activator Activity Translation Initiation Factor Binding Ribosomal Small Subunit Binding Cadherin Binding MRNA 5'-UTR Binding
	Biological Process	Response To Mechanical Stimulus Wound Healing Intermediate Filament Cytoskeleton Organization Cornification	Translational Initiation Cell Population Proliferation Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Macroautophagy Negative Regulation Of Translation TOR Signaling TORC1 Signaling Positive Regulation Of Viral Genome Replication Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation MRNA Stabilization Cellular Response To Rapamycin Response To Amino Acid Starvation
Pathways		Formation of the cornified envelope Butyrophilin (BTN) family interactions
Drugs
Diseases
GWAS		Adult body size ( 32376654) Cancer ( 29299148) Diastolic blood pressure ( 28135244 27841878) Height ( 28552196) Lung cancer (asbestos exposure interaction) ( 22637743) Metabolite levels (HVA/MHPG ratio) ( 23319000) Mitochondrial DNA copy number (white blood cells) ( 30704525) Systolic blood pressure ( 27841878)	Chin dimples ( 27182965) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Monobrow ( 27182965) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		43 interacting genes: ACTR5 AHCYL1 AKT1 ALAS1 C6orf141 CASP6 CEP57L1 COL17A1 DES EVPL HECTD3 IKZF1 ITSN1 KAZN KCTD21 KNSTRN KRT25 KRT39 KRT8 MRPL28 OPRM1 PBX4 PICK1 PLEKHA7 POF1B PPHLN1 PTEN RAB3IP SKIL TRAF2 TRIM27 TSC22D4 UBC UPRT USP7 VIM ZBTB26 ZNF165 ZNF213 ZNF263 ZNF474 ZSCAN1 ZSCAN16	9 interacting genes: BCL2L1 CSNK2A1 KASH5 SRPK1 TNNT1 YWHAB YWHAG YWHAQ YWHAZ
Entrez ID		5493	23367
HPRD ID		04187	11225
Ensembl ID		ENSG00000118898	ENSG00000155506
Uniprot IDs		O60437	Q6PKG0
PDB IDs		4Q28	4ZC4 5C0V 5V4R 5V7C 5V87 6PW3
Enriched GO Terms of Interacting Partners?
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