PPL and KRT25

Data Source:
BioGRID (two hybrid)

		PPL	KRT25
Description		periplakin	keratin 25
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Membrane Desmosome Extracellular Exosome	Cytosol Intermediate Filament Extracellular Exosome
	Molecular Function	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cadherin Binding	Molecular_function Structural Molecule Activity Protein Binding Protein Heterodimerization Activity
	Biological Process	Response To Mechanical Stimulus Wound Healing Intermediate Filament Cytoskeleton Organization Cornification	Cytoskeleton Organization Aging Hair Follicle Morphogenesis Keratinization Hair Cycle Intermediate Filament Organization Cornification
Pathways		Formation of the cornified envelope Butyrophilin (BTN) family interactions	Keratinization Formation of the cornified envelope
Drugs
Diseases
GWAS		Adult body size ( 32376654) Cancer ( 29299148) Diastolic blood pressure ( 28135244 27841878) Height ( 28552196) Lung cancer (asbestos exposure interaction) ( 22637743) Metabolite levels (HVA/MHPG ratio) ( 23319000) Mitochondrial DNA copy number (white blood cells) ( 30704525) Systolic blood pressure ( 27841878)	Asthma ( 31959851 30929738) Cognitive decline rate in late mild cognitive impairment ( 26252872)
Interacting Genes		43 interacting genes: ACTR5 AHCYL1 AKT1 ALAS1 C6orf141 CASP6 CEP57L1 COL17A1 DES EVPL HECTD3 IKZF1 ITSN1 KAZN KCTD21 KNSTRN KRT25 KRT39 KRT8 MRPL28 OPRM1 PBX4 PICK1 PLEKHA7 POF1B PPHLN1 PTEN RAB3IP SKIL TRAF2 TRIM27 TSC22D4 UBC UPRT USP7 VIM ZBTB26 ZNF165 ZNF213 ZNF263 ZNF474 ZSCAN1 ZSCAN16	22 interacting genes: HGS KRT1 KRT2 KRT3 KRT4 KRT5 KRT6A KRT6B KRT6C KRT71 KRT72 KRT74 KRT75 KRT76 KRT78 KRT79 KRT8 KRT83 KRT85 KRT86 MORN4 PPL
Entrez ID		5493	147183
HPRD ID		04187	17242
Ensembl ID		ENSG00000118898	ENSG00000204897
Uniprot IDs		O60437	Q6ZPD6 Q7Z3Z0
PDB IDs		4Q28
Enriched GO Terms of Interacting Partners?
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