SEMA4C and KRT16

Data Source:
BioGRID (two hybrid)

		SEMA4C	KRT16
Description		semaphorin 4C	keratin 16
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Integral Component Of Plasma Membrane Postsynaptic Density Synaptic Vesicle Membrane Postsynaptic Density Membrane	Nucleus Cytosol Cytoskeleton Intermediate Filament Extracellular Exosome
	Molecular Function	Protein Binding Semaphorin Receptor Binding Chemorepellent Activity	Structural Constituent Of Cytoskeleton Protein Binding
	Biological Process	Neural Crest Cell Migration Neural Tube Closure Axon Guidance Cell Migration In Hindbrain Cerebellum Development Positive Regulation Of Cell Migration Positive Regulation Of Stress-activated MAPK Cascade Muscle Cell Differentiation Negative Regulation Of Axon Extension Involved In Axon Guidance Negative Chemotaxis Semaphorin-plexin Signaling Pathway	Morphogenesis Of An Epithelium Inflammatory Response Cytoskeleton Organization Aging Keratinocyte Differentiation Negative Regulation Of Cell Migration Keratinization Hair Cycle Innate Immune Response Intermediate Filament Cytoskeleton Organization Keratinocyte Migration Establishment Of Skin Barrier Cornification
Pathways			Keratinization Formation of the cornified envelope
Drugs			Zinc Zinc acetate
Diseases			Non-epidermolytic palmoplantar keratoderma (NEPPK) Pachyonychia congenita, including: Jadassohn-Lewandowsky syndrome; Jackson-Lawler syndrome ; Steatocystoma multiplex
GWAS		Blood protein levels ( 30072576)
Interacting Genes		20 interacting genes: CYSRT1 DLG1 DLG2 DLG3 DLG4 GIPC1 HSF2BP KRT16 KRT27 KRT31 KRT34 KRT40 KRTAP6-3 NBPF19 NCDN NOTCH2NLA PNMA1 RCHY1 TRIM54 USHBP1	56 interacting genes: AMOT ARFIP2 C1orf109 C1orf216 CARD9 CCDC146 CCDC17 CCHCR1 CCNC CDK18 CYTH4 EPM2AIP1 GAS8 GNG10 HGS KIFC3 KLC4 KRT1 KRT2 KRT3 KRT4 KRT5 KRT6A KRT6C KRT71 KRT72 KRT73 KRT74 KRT76 KRT78 KRT79 KRT8 KRT80 KRT81 KRT83 KRT85 KRT86 LMO1 LNX1 MBD3 PKN1 POLL PPP1R18 PRKAA2 PRPH PUS10 SEMA4C SGF29 SMARCD1 SMARCE1 SNAPIN TCHP TSG101 TTC23 TXLNB USHBP1
Entrez ID		54910	3868
HPRD ID		07257	01018
Ensembl ID		ENSG00000168758	ENSG00000186832
Uniprot IDs		Q9C0C4	P08779
PDB IDs		6N5Z
Enriched GO Terms of Interacting Partners?
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