BCOR and CPNE1

Data Source:
HPRD (in vitro)

		BCOR	CPNE1
Description		BCL6 corepressor	copine 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm BCOR Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Membrane Azurophil Granule Membrane Extracellular Exosome
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Corepressor Activity Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Heat Shock Protein Binding Histone Deacetylase Binding	Phosphatidylserine Binding Endopeptidase Activity Transporter Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Identical Protein Binding NF-kappaB Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Histone H3-K36 Methylation Blastocyst Hatching Heart Development Negative Regulation Of Bone Mineralization Histone H2A Monoubiquitination Odontogenesis Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Histone H3-K4 Methylation Roof Of Mouth Development Specification Of Axis Polarity Negative Regulation Of Tooth Mineralization	Proteolysis Lipid Metabolic Process Negative Regulation Of Gene Expression Vesicle-mediated Transport Regulation Of I-kappaB Kinase/NF-kappaB Signaling Neutrophil Degranulation Negative Regulation Of DNA Binding Positive Regulation Of Neuron Differentiation Glycerophospholipid Biosynthetic Process Positive Regulation Of Protein Kinase B Signaling Cellular Response To Calcium Ion Negative Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Neuron Projection Extension
Pathways			Glycerophospholipid biosynthesis Neutrophil degranulation
Drugs			Theophylline
Diseases		Anophthalmia and microphthalmia (A/M)
GWAS		Pit-and-Fissure caries ( 23470693) Platelet count ( 29403010) Refractive error ( 32231278) Venous thromboembolism ( 31676865)	Blood protein levels ( 30072576 29875488 28240269) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		17 interacting genes: BCL6 CPNE1 CPNE2 CPNE4 HDAC1 HDAC3 HDAC4 HDAC5 HDAC6 MLLT3 NAA10 NACC1 PCGF1 PCGF3 SP1 UBTD1 USP7	20 interacting genes: ACTB BCOR BUB3 CCDC22 CPNE4 LHX6 LIG4 MAP2K1 MYCBP PDCD6 PITPNM2 PPP5C RDX SKIL SORBS3 SPTBN1 STK3 UBE2M UBE2O WTAP
Entrez ID		54880	8904
HPRD ID		06458	05014
Ensembl ID		ENSG00000183337	ENSG00000214078
Uniprot IDs		Q6W2J9	B0QZ18 Q99829
PDB IDs		2N1L 3BIM 4HPL 6B7G
Enriched GO Terms of Interacting Partners?
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