POU5F1 and SOX2

Data Source:
HPRD (in vitro)

		POU5F1	SOX2
Description		POU class 5 homeobox 1	SRY-box transcription factor 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding Ubiquitin Protein Ligase Binding MiRNA Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding MiRNA Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endodermal Cell Fate Specification Blastocyst Development Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Response To Wounding Anatomical Structure Morphogenesis Regulation Of Asymmetric Cell Division Regulation Of Gene Expression Somatic Stem Cell Population Maintenance Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Silencing By MiRNA Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Eye Development Endodermal Cell Fate Specification Chromatin Organization Regulation Of Transcription, DNA-templated Cell Cycle Arrest Response To Wounding Anatomical Structure Morphogenesis Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Glial Cell Fate Commitment Pituitary Gland Development Adenohypophysis Development Positive Regulation Of Cell-cell Adhesion Cell Differentiation Forebrain Development Somatic Stem Cell Population Maintenance Tissue Regeneration Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of MAPK Cascade Cell Fate Commitment Positive Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Inner Ear Development Negative Regulation Of Epithelial Cell Proliferation Response To Growth Factor Negative Regulation Of Canonical Wnt Signaling Pathway Neuronal Stem Cell Population Maintenance
Pathways		POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation of pluripotent stem cells	POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Deactivation of the beta-catenin transactivating complex Transcriptional regulation of pluripotent stem cells Interleukin-4 and Interleukin-13 signaling Transcriptional Regulation by MECP2
Drugs
Diseases			Anophthalmia and microphthalmia (A/M) Septo-optic dysplasia
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Cold sores ( 28928442) Drug-induced Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN) ( 21801394) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 27863252) Malaria ( 31844061) Multiple myeloma ( 23955597) Night sleep phenotypes ( 27126917) Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) ( 21912425) Type 2 diabetes ( 24509480 30718926 28869590) Ulcerative colitis ( 28067908)	Adult body size ( 32376654) Age-related nuclear cataracts ( 33311586) Cataracts (operation) ( 31816047) Chronotype ( 30696823) Excessive hairiness ( 29895819) Eyebrow thickness ( 30248107) General risk tolerance (MTAG) ( 30643258) Monobrow ( 27182965) Night sleep phenotypes ( 27126917) Self-reported risk-taking behaviour ( 30181555) Toxoplasma gondii sag1 antibody levels ( 33204752)
Interacting Genes		15 interacting genes: AR ETS2 EWSR1 FOXD3 HMGB1 HMGB2 ITCH LRRK2 MNAT1 NR0B1 SOX10 SOX2 SOX8 STUB1 WDR5	17 interacting genes: AKT1 ALX4 CASP8 CDX1 COP1 FZR1 L3MBTL3 MAPK3 NR5A1 OTUD7B POU2F1 POU5F1 SETD7 SUMO1 UBE2D3 UBR5 XPO1
Entrez ID		5460	6657
HPRD ID		01252	08921
Ensembl ID		ENSG00000204531	ENSG00000181449
Uniprot IDs		D2IYK3 F2Z381 M1S623 Q01860	A0A0U3FYV6 P48431
PDB IDs		6T90 6YOV	1O4X 2LE4 6T7B 6T90 6WX7 6WX8 6WX9 6YOV
Enriched GO Terms of Interacting Partners?
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