POU5F1 and NR0B1

Data Source:
BioGRID (pull down)

		POU5F1	NR0B1
Description		POU class 5 homeobox 1	nuclear receptor subfamily 0 group B member 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol	Chromatin Nucleus Nucleoplasm Cytoplasm Membrane Nuclear Speck Centriolar Satellite Polysomal Ribosome Intracellular Membrane-bounded Organelle
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding Ubiquitin Protein Ligase Binding MiRNA Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Transcription Corepressor Activity RNA Binding Protein Binding Transcription Factor Binding Protein Domain Specific Binding DNA Hairpin Binding Steroid Hormone Receptor Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endodermal Cell Fate Specification Blastocyst Development Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Response To Wounding Anatomical Structure Morphogenesis Regulation Of Asymmetric Cell Division Regulation Of Gene Expression Somatic Stem Cell Population Maintenance Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Silencing By MiRNA Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Spermatogenesis Protein Localization Gonad Development Male Gonad Development Negative Regulation Of Steroid Biosynthetic Process Hypothalamus Development Pituitary Gland Development Male Sex Determination Adrenal Gland Development Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Leydig Cell Differentiation Response To Immobilization Stress Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Sertoli Cell Differentiation
Pathways		POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation of pluripotent stem cells
Drugs			Dexamethasone Dexamethasone acetate
Diseases			Glycerol kinase deficiency (GKD), including: Hyperglycerolemia; Chromosome Xp21 deletion syndrome; Adrenal hypoplasia, congenital (AHC); Duchenne muscular dystrophy (DMD) 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Cold sores ( 28928442) Drug-induced Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN) ( 21801394) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 27863252) Malaria ( 31844061) Multiple myeloma ( 23955597) Night sleep phenotypes ( 27126917) Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) ( 21912425) Type 2 diabetes ( 24509480 30718926 28869590) Ulcerative colitis ( 28067908)
Interacting Genes		15 interacting genes: AR ETS2 EWSR1 FOXD3 HMGB1 HMGB2 ITCH LRRK2 MNAT1 NR0B1 SOX10 SOX2 SOX8 STUB1 WDR5	17 interacting genes: AR COPS2 EEF2KMT ESR1 ESR2 ESRRA ESRRG NR3C1 NR5A1 NRIP1 PGR POU5F1 PPARG RNF31 RORA SNW1 SREBF1
Entrez ID		5460	190
HPRD ID		01252	08362
Ensembl ID		ENSG00000204531	ENSG00000169297
Uniprot IDs		D2IYK3 F2Z381 M1S623 Q01860	F1D8P4 P51843
PDB IDs		6T90 6YOV	4RWV
Enriched GO Terms of Interacting Partners?
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