POLA1 and IL1RAPL1

Data Source:
HPRD (in vitro, two hybrid)

		POLA1	IL1RAPL1
Description		DNA polymerase alpha 1, catalytic subunit	interleukin 1 receptor accessory protein like 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nuclear Envelope Nucleoplasm Alpha DNA Polymerase:primase Complex Nucleolus Cytosol Nuclear Matrix	Cytoplasm Plasma Membrane Cell Surface Integral Component Of Membrane Axon Dendrite Postsynaptic Membrane Glutamatergic Synapse
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Purine Nucleotide Binding Pyrimidine Nucleotide Binding Protein Kinase Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding	Signaling Receptor Binding Protein Binding Interleukin-1 Binding NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle DNA Synthesis Involved In DNA Repair DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Leading Strand Elongation Lagging Strand Elongation DNA Repair Nucleotide-excision Repair Double-strand Break Repair Via Nonhomologous End Joining Viral Process Telomere Maintenance Via Semi-conservative Replication Regulation Of Type I Interferon Production Mitotic DNA Replication Initiation DNA Synthesis Involved In UV-damage Excision Repair	Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Signal Transduction Regulation Of Neuron Projection Development Neuron Differentiation Negative Regulation Of Exocytosis Positive Regulation Of Dendrite Morphogenesis Positive Regulation Of Synapse Assembly Cellular Response To Cytokine Stimulus Presynaptic Membrane Assembly Regulation Of Postsynapse Organization Trans-synaptic Signaling By Trans-synaptic Complex Regulation Of Presynapse Assembly
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand G1/S-Specific Transcription	Receptor-type tyrosine-protein phosphatases Interleukin-38 signaling
Drugs		Cladribine Clofarabine Fludarabine Nelarabine
Diseases			Non-syndromic X-linked mental retardation
GWAS		Mean platelet volume ( 32888494) Platelet count ( 32888494)	Cardiovascular risk factors (age interaction) ( 20838585) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Vitiligo ( 27723757)
Interacting Genes		20 interacting genes: CCNA2 CCNB1 CDC45 CDK1 CDK2 CDK2AP1 GINS4 HELB PARP1 POLA2 POLE PRIM2 RAD51 RB1 RBMS1 SERPINA3 SMC1A SUMO2 TP53 XRCC5	2 interacting genes: ARHGAP22 NCS1
Entrez ID		5422	11141
HPRD ID		02416	02193
Ensembl ID		ENSG00000101868	ENSG00000169306
Uniprot IDs		A6NMQ1 P09884	Q9NZN1 X5DNQ7
PDB IDs		1K0P 1K18 1N5G 4Q5V 4QCL 4Y97 5EXR 5IUD 6AS7	1T3G 4M92 5WY8
Enriched GO Terms of Interacting Partners?
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