ERRFI1 and DCTN6

Data Source:
BioGRID (two hybrid)

		ERRFI1	DCTN6
Description		ERBB receptor feedback inhibitor 1	dynactin subunit 6
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Condensed Chromosome Kinetochore Centrosome Cytosol Dynactin Complex
	Molecular Function	GTPase Activator Activity Protein Binding SH3 Domain Binding Protein Kinase Binding Small GTPase Binding	Dynein Complex Binding
	Biological Process	Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Protein Autophosphorylation Negative Regulation Of Interleukin-1 Beta Production Cellular Response To Insulin Stimulus Negative Regulation Of Collagen Biosynthetic Process Cellular Response To Platelet-derived Growth Factor Stimulus Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of GTPase Activity Skin Morphogenesis Regulation Of Keratinocyte Differentiation Lung Alveolus Development Lung Vasculature Development Lung Epithelium Development Regulation Of Type B Pancreatic Cell Proliferation Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Cellular Hyperosmotic Response Cellular Response To Dexamethasone Stimulus Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Mitotic Spindle Organization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Pathways			MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		Crohn's disease ( 28067908) Hair shape ( 29220522) Inflammatory bowel disease ( 28067908) Ischemic stroke ( 24262325) Morning person ( 30696823) Response to antidepressants and depression ( 27622933) Strep throat ( 28928442) Ulcerative colitis ( 28067908)	Breast size ( 27182965)
Interacting Genes		60 interacting genes: ACBD3 ADAM5 AGPAT4-IT1 AOX1 ARRDC5 ATM AURKA BAG4 BCAR3 CASP8 CDC42 CIAO2B COPS5 CRHBP DCTN6 EFEMP1 EGFR ERBB2 FGFR2 FGFR4 FYN GAS1 GNPDA2 GRB2 GTF2H2 HYDIN IL2RG MFSD5 MMP26 NEDD4 NEU1 NPC2 OSTF1 PALB2 PAPSS1 PCCA PCNA PDCD2 PHYHIPL PLEKHA3 PPIA PPM1D PSMA7 PSMB6 RAB18 RB1CC1 RUBCNL SH3YL1 SLC7A13 SMIM30 SRC TC2N TIMP4 TM2D3 TMEM165 TMEM59 WDR61 WEE1 YWHAB ZPBP	7 interacting genes: APP CDK1 ERRFI1 HSPB2 NCOA3 PMEPA1 RPSA
Entrez ID		54206	10671
HPRD ID		09218	09907
Ensembl ID		ENSG00000116285	ENSG00000104671
Uniprot IDs		B3KTV8 I6S2Y9 Q9UJM3	O00399
PDB IDs		2RF9 2RFD 2RFE 4I21 4R3P 4R3R 4ZJV	3TV0
Enriched GO Terms of Interacting Partners?
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