PMS2 and TRMO

Data Source:
BioGRID (two hybrid)

		PMS2	TRMO
Description		PMS1 homolog 2, mismatch repair system component	tRNA methyltransferase O
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane Mismatch Repair Complex MutLalpha Complex Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	DNA Binding Single-stranded DNA Binding Endonuclease Activity Protein Binding ATP Binding ATPase Activity Single Base Insertion Or Deletion Binding MutSalpha Complex Binding	Protein Binding TRNA (adenine-N6-)-methyltransferase Activity
	Biological Process	Mismatch Repair Somatic Hypermutation Of Immunoglobulin Genes Response To Drug Nucleic Acid Phosphodiester Bond Hydrolysis	TRNA Methylation
Pathways		Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MLH1 Defective Mismatch Repair Associated With PMS2 TP53 Regulates Transcription of DNA Repair Genes
Drugs		Adenosine 5'-[gamma-thio]triphosphate
Diseases		Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS			Orofacial clefts ( 33137956)
Interacting Genes		16 interacting genes: AKT1 ANP32B CCDC180 EXO1 FANCC GALNT12 MEOX2 MLH1 PCNA PPP2CB RASA1 SFRP4 TRMO UBC XPA ZNF189	23 interacting genes: AURKA BCL10 BMPR1A BUB1 CCND1 DCC DLC1 EGFR ERBB2 MCC MLH1 NRAS PMS2 PTEN PTPRJ RAD54B RB1 SMAD2 SPATC1L SRC STAC STK11 TGFBR2
Entrez ID		5395	51531
HPRD ID		02598	12945
Ensembl ID		ENSG00000122512	ENSG00000136932
Uniprot IDs		A0A2R8Y6S3 B4DGM0 C9J167 P54278 Q7Z3Q2	Q5T114 Q9BU70
PDB IDs		1EA6 1H7S 1H7U 5U5R 6MFQ
Enriched GO Terms of Interacting Partners?
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