TRMO and PMS2

Data Source:
BioGRID (two hybrid)

		TRMO	PMS2
Description		tRNA methyltransferase O	PMS1 homolog 2, mismatch repair system component
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Cytosol Plasma Membrane Mismatch Repair Complex MutLalpha Complex Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Protein Binding TRNA (adenine-N6-)-methyltransferase Activity	DNA Binding Single-stranded DNA Binding Endonuclease Activity Protein Binding ATP Binding ATPase Activity Single Base Insertion Or Deletion Binding MutSalpha Complex Binding
	Biological Process	TRNA Methylation	Mismatch Repair Somatic Hypermutation Of Immunoglobulin Genes Response To Drug Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways			Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MLH1 Defective Mismatch Repair Associated With PMS2 TP53 Regulates Transcription of DNA Repair Genes
Drugs			Adenosine 5'-[gamma-thio]triphosphate
Diseases			Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS		Orofacial clefts ( 33137956)
Interacting Genes		23 interacting genes: AURKA BCL10 BMPR1A BUB1 CCND1 DCC DLC1 EGFR ERBB2 MCC MLH1 NRAS PMS2 PTEN PTPRJ RAD54B RB1 SMAD2 SPATC1L SRC STAC STK11 TGFBR2	16 interacting genes: AKT1 ANP32B CCDC180 EXO1 FANCC GALNT12 MEOX2 MLH1 PCNA PPP2CB RASA1 SFRP4 TRMO UBC XPA ZNF189
Entrez ID		51531	5395
HPRD ID		12945	02598
Ensembl ID		ENSG00000136932	ENSG00000122512
Uniprot IDs		Q5T114 Q9BU70	A0A2R8Y6S3 B4DGM0 C9J167 P54278 Q7Z3Q2
PDB IDs			1EA6 1H7S 1H7U 5U5R 6MFQ
Enriched GO Terms of Interacting Partners?
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