PLXNB1 and ARHGEF12

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		PLXNB1	ARHGEF12
Description		plexin B1	Rho guanine nucleotide exchange factor 12
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GO Annotations	Cellular Component	Semaphorin Receptor Complex Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane	Cytoplasm Cytosol Membrane Extracellular Exosome
	Molecular Function	Transmembrane Signaling Receptor Activity GTPase Activator Activity Protein Binding Semaphorin Receptor Activity Semaphorin Receptor Binding GTPase Activating Protein Binding Signaling Receptor Activity	G Protein-coupled Receptor Binding Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	Negative Regulation Of Cell Adhesion Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Shape Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Regulation Of Cell Migration Negative Regulation Of Osteoblast Proliferation Intracellular Signal Transduction Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Ossification Involved In Bone Maturation Neuron Projection Morphogenesis Positive Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Semaphorin-plexin Signaling Pathway Semaphorin-plexin Signaling Pathway Involved In Bone Trabecula Morphogenesis Semaphorin-plexin Signaling Pathway Involved In Axon Guidance Inhibitory Synapse Assembly	G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		G alpha (12/13) signalling events Sema4D mediated inhibition of cell attachment and migration Sema4D induced cell migration and growth-cone collapse	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31152163) Inflammatory bowel disease ( 28067908) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Attention deficit hyperactivity disorder symptom score ( 27663945) Coronary artery disease ( 29212778 30104761) Glaucoma ( 31959993 30054594) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 29891935 25173105) Height ( 31562340) Intraocular pressure ( 29617998 25637523 31798171 29785010 31959993 30054594 28073927 29235454) Platelet count ( 32888494) Plateletcrit ( 32888494) White blood cell count ( 32888494)
Interacting Genes		14 interacting genes: ARHGEF11 ARHGEF12 KMT2A L1CAM MET NRP1 NRP2 PLXNA1 RAC1 RND1 RND3 SEMA4B SEMA4D SOX4	17 interacting genes: ABCA1 CD44 CLK1 CUL3 EGFR GNA12 GNA13 IGF1R KLHL20 LPAR1 LPAR2 PLXNB1 PLXNB2 PTPRF RHOA RPS6KA1 TEC
Entrez ID		5364	23365
HPRD ID		03032	09207
Ensembl ID		ENSG00000164050	ENSG00000196914
Uniprot IDs		O43157	B4E2K6 E9PMR6 Q9NZN5
PDB IDs		2JPH 2OS6 2R2O 2REX 3HM6 3OL2 3SU8 3SUA 5B4W	1TXD 1X86 2OMJ 2OS6
Enriched GO Terms of Interacting Partners?
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