MBD3 and RAB3IP

Data Source:
BioGRID (two hybrid)

		MBD3	RAB3IP
Description		methyl-CpG binding domain protein 3	RAB3A interacting protein
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GO Annotations	Cellular Component	Chromatin Heterochromatin Nucleoplasm Cytoplasm NuRD Complex Protein-containing Complex	Nucleus Cytosol Cytoskeleton Lamellipodium Golgi To Plasma Membrane Transport Vesicle
	Molecular Function	DNA Binding Protein Binding Methyl-CpG Binding Nucleosomal DNA Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development DNA Methylation-dependent Heterochromatin Assembly Brain Development Heart Development Aging Tissue Development Histone Acetylation Response To Nutrient Levels Response To Estradiol ATP-dependent Chromatin Remodeling Regulation Of DNA Methylation Embryonic Organ Development Regulation Of Signal Transduction By P53 Class Mediator	Protein Targeting To Membrane Exocytosis Regulation Of Catalytic Activity Ciliary Basal Body-plasma Membrane Docking
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS	Anchoring of the basal body to the plasma membrane VxPx cargo-targeting to cilium BBSome-mediated cargo-targeting to cilium RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS			Diastolic blood pressure ( 27841878) Height ( 28552196) Logical memory (delayed recall) in normal cognition ( 29274321)
Interacting Genes		76 interacting genes: AGR2 ANKRD33 ASCL4 ATF7 AURKA BCL11B CCDC183 CCHCR1 CCNC CENPP CEP70 CEP76 CT55 ERCC6 EXOC4 FAM136A GADD45GIP1 GATAD2A GATAD2B GOLGA2 GOLGA6L9 H3-4 HDAC1 ICA1 IGFBP6 IK JUN KDM1A KDM5B KRT15 KRT16 LDOC1 LMO3 MAGEA2 MAGEA2B MBD2 MBD3L1 MBD3L2 MECOM MEIS3 MEOX1 MEOX2 MIPOL1 MKRN3 MTA2 MTUS2 MYOG NUTM1 PBX4 PDGFA PFDN6 PICK1 PKNOX2 PRKAR1B RAB3IP RBBP4 RBBP7 RCN3 REL RINT1 SDCBP SERTAD3 SMARCA4 SPEN STMN2 SYCE1 TBC1D19 TET1 TIMM10B TNNI1 TRIM54 TTC23 USP11 ZBTB7A ZNF277 ZNF655	32 interacting genes: BANP CCDC196 CHCHD3 DNAJB13 FAM124A KRT40 MB21D2 MBD3 MVP NAA10 PEG10 PKN1 PLOD3 PPL PRKAB2 RAB11A RAB3A RAB3D RAB3IL1 RAB8A RAB8B RUFY1 SFN SSX2 SUV39H2 TBC1D21 TEPSIN TRAPPC6A TXNDC5 ZBTB16 ZNF410 ZNF76
Entrez ID		53615	117177
HPRD ID		04653	10565
Ensembl ID		ENSG00000071655	ENSG00000127328
Uniprot IDs		O95983	Q96QF0
PDB IDs		2MB7 6CC8 6CCG 6CEU 6CEV	4LHX 4LHY 4LHZ 4UJ3 4UJ4 4UJ5 6F6P
Enriched GO Terms of Interacting Partners?
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