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RAB3IP and PKN1
Data Source:
BioGRID
(two hybrid)
RAB3IP
PKN1
Description
RAB3A interacting protein
protein kinase N1
Image
GO Annotations
Cellular Component
Nucleus
Cytosol
Cytoskeleton
Lamellipodium
Golgi To Plasma Membrane Transport Vesicle
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Cytosol
Midbody
Cleavage Furrow
Protein-containing Complex
Molecular Function
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
Chromatin Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Calcium-dependent Protein Kinase C Activity
Protein Kinase C Binding
Protein Binding
ATP Binding
Nuclear Receptor Coactivator Activity
Small GTPase Binding
Histone Kinase Activity (H3-T11 Specific)
Histone Binding
Histone Deacetylase Binding
Androgen Receptor Binding
Biological Process
Protein Targeting To Membrane
Exocytosis
Regulation Of Catalytic Activity
Ciliary Basal Body-plasma Membrane Docking
B Cell Homeostasis
B Cell Apoptotic Process
Regulation Of Germinal Center Formation
Regulation Of Immunoglobulin Production
Renal System Process
Regulation Of Transcription By RNA Polymerase II
Protein Phosphorylation
Negative Regulation Of Protein Kinase Activity
Hyperosmotic Response
Signal Transduction
Activation Of JUN Kinase Activity
Epithelial Cell Migration
Peptidyl-serine Phosphorylation
Negative Regulation Of B Cell Proliferation
Histone H3-T11 Phosphorylation
Intracellular Signal Transduction
Positive Regulation Of Transcription, DNA-templated
Spleen Development
Regulation Of Cell Motility
Pathways
Anchoring of the basal body to the plasma membrane
VxPx cargo-targeting to cilium
BBSome-mediated cargo-targeting to cilium
RAB GEFs exchange GTP for GDP on RABs
RHO GTPases activate PKNs
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Drugs
Fostamatinib
Diseases
GWAS
Diastolic blood pressure (
27841878
)
Height (
28552196
)
Logical memory (delayed recall) in normal cognition (
29274321
)
Pancreatic cancer (
30206226
)
Urolithiasis (
30975718
)
Interacting Genes
32 interacting genes:
BANP
CCDC196
CHCHD3
DNAJB13
FAM124A
KRT40
MB21D2
MBD3
MVP
NAA10
PEG10
PKN1
PLOD3
PPL
PRKAB2
RAB11A
RAB3A
RAB3D
RAB3IL1
RAB8A
RAB8B
RUFY1
SFN
SSX2
SUV39H2
TBC1D21
TEPSIN
TRAPPC6A
TXNDC5
ZBTB16
ZNF410
ZNF76
83 interacting genes:
ACTN1
ADAMTSL4
AKAP9
ARHGAP10
ARHGAP26
ARSA
BLZF1
BUD23
CASP3
CCDC103
CCDC136
CCDC138
CCDC85B
CCNT2
CD44
CDC25C
CDR2
CEP57
CEP57L1
CEP70
CYSRT1
DISC1
DYDC1
EIF3F
GOLGA2
GOLGA6L9
H3C14
HAP1
HAUS1
HDAC5
HOMER3
HSF2BP
INTS11
KIAA1328
KRT15
KRT16
KRT19
KRT31
KRT34
KRT35
KRT36
KRT37
LRRC61
MAP2K6
MAPK12
MAPT
MARCKS
MBP
MID1
MID2
MIPOL1
MKRN3
MTDH
MTUS2
NEFH
NEFL
NEUROD2
PDPK1
PICK1
PLD1
PNMA1
POU6F2
PSMB4
RAB3IP
RHOA
SERTAD3
SMYD3
SPAG5
SPRR2D
SSX2IP
STX11
SYCE3
TNFRSF1B
TRAF1
TRAF2
TRIM27
TSGA10
UBR2
USHBP1
VIM
ZFAND6
ZNF282
ZRANB1
Entrez ID
117177
5585
HPRD ID
10565
03019
Ensembl ID
ENSG00000127328
ENSG00000123143
Uniprot IDs
Q96QF0
Q16512
PDB IDs
4LHX
4LHY
4LHZ
4UJ3
4UJ4
4UJ5
6F6P
1CXZ
1URF
2RMK
4NKG
4OTD
4OTG
4OTH
4OTI
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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