PLP1 and TMEM182

Data Source:
BioGRID (two hybrid)

		PLP1	TMEM182
Description		proteolipid protein 1	transmembrane protein 182
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integrin Alphav-beta3 Complex Myelin Sheath Synapse	Integral Component Of Membrane
	Molecular Function	Structural Molecule Activity Protein Binding Structural Constituent Of Myelin Sheath	Protein Binding
	Biological Process	Inflammatory Response Chemical Synaptic Transmission Axon Ensheathment Positive Regulation Of Gene Expression Astrocyte Development Substantia Nigra Development Central Nervous System Myelination Positive Regulation Of Cell Migration Neuron Projection Development Long-chain Fatty Acid Biosynthetic Process Axon Development AMPA Selective Glutamate Receptor Signaling Pathway Positive Regulation Of Calcium Ion Transmembrane Transport
Pathways
Drugs
Diseases		Hereditary spastic paraplegia (SPG) Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD)
GWAS			Adult body size ( 32376654) Age at first sexual intercourse ( 27089180) Blood pressure ( 24903457) Blood pressure (anthropometric measures interaction) ( 24903457) Chromium levels ( 26025379) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) General risk tolerance (MTAG) ( 30643258) Night sleep phenotypes ( 27126917) Number of sexual partners ( 30643258) Photic sneeze reflex ( 27182965) PR interval ( 30046033 32439900) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking initiation ( 30617275) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		86 interacting genes: ADGRG3 AKT1 AQP10 AQP6 ARL13B BCL2L13 BIK CALN1 CALR CANX CD40 CD74 CDIPT CLDN2 CLDN20 CLEC2D CLN8 CREB3 CREB3L1 CYBC1 DCT DYSF EDA2R ELOVL4 ERGIC3 FAM209A FCRL2 FFAR2 FNDC9 GAST GPR42 GPR61 HAS3 HTR2C IER3IP1 IFITM3 ITGAV JAGN1 JPH1 KLRC1 LEPROTL1 LEUTX LHFPL5 LMNA MAG MBP MFF MGST3 MS4A3 MS4A4A MTIF3 MUC1 MYADM NRG1 PI16 PIGP PTPRN RELL2 RMDN3 RNF24 SLC10A6 SLC16A2 SLC18A1 SLC1A5 SLC26A6 SLC35E2A SLC35E3 SLC41A3 SMIM3 SPNS3 STX1A STX4 SUSD3 TMEM106C TMEM14B TMEM182 TMEM242 TMEM243 TMEM254 TMEM31 TMEM45B TMEM52B TMEM97 TMPRSS2 UPK2 VAT1	15 interacting genes: CLDN5 FNDC9 GJA8 GPR42 KLRC1 MALL MS4A3 PLP1 SMIM3 SUSD3 SYNE4 TMEM140 TMEM218 TMEM31 TSPAN12
Entrez ID		5354	130827
HPRD ID		02321	08698
Ensembl ID		ENSG00000123560	ENSG00000170417
Uniprot IDs		A0A0S2Z4D4 A8K9L3 B4DI30 P60201	Q6ZP80
PDB IDs		2XPG
Enriched GO Terms of Interacting Partners?
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