TM6SF2 and ARL13B

Data Source:
BioGRID (two hybrid)

		TM6SF2	ARL13B
Description		transmembrane 6 superfamily member 2	ADP ribosylation factor like GTPase 13B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Cilium Motile Cilium Ciliary Membrane Non-motile Cilium
	Molecular Function	Molecular_function Protein Binding Identical Protein Binding	Protein Binding GTP Binding
	Biological Process	Lipid Metabolic Process Regulation Of Lipid Metabolic Process Lipid Homeostasis	Smoothened Signaling Pathway Neural Tube Patterning Interneuron Migration From The Subpallium To The Cortex Formation Of Radial Glial Scaffolds Cilium Assembly Receptor Localization To Non-motile Cilium Non-motile Cilium Assembly
Pathways			ARL13B-mediated ciliary trafficking of INPP5E Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy
Drugs
Diseases			Joubert syndrome
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Cirrhosis (alcohol related) ( 26482880) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Liver fat content (MRI proton density fat fraction measure) ( 32247823) Liver fibrosis and steatohepatitis severity (MRI cT1 measure) ( 32247823) Low density lipoprotein cholesterol levels ( 32154731) Medication use (HMG CoA reductase inhibitors) ( 31015401) Nonalcoholic fatty liver disease ( 24531328 29385134) Nonalcoholic steatohepatitis ( 32298765) Schizophrenia ( 25056061 29483656 23974872) Triglyceride levels ( 32203549 32154731 29403010) Type 2 diabetes ( 30297969 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382) Vitamin levels ( 23696881)
Interacting Genes		10 interacting genes: ARL13B BCL2L13 FAM209A HIBADH KCNJ6 MUC1 PVR SCN3B SSMEM1 TMEM237	130 interacting genes: ACSF2 AIG1 ALG3 ANKRD46 AOC3 AQP10 B4GALNT2 BMP10 BNIP3 BRICD5 C1GALT1 C2CD2L C4orf3 CCDC167 CCL4 CCL4L2 CD151 CD302 CD53 CDIPT CFHR5 CLDN4 CLDN8 CLEC4G CLEC7A CLN6 CMTM3 CMTM7 COL8A2 CSGALNACT2 CTSA CXCL16 CYB561D2 EBP EMP1 ENTPD3 FAXDC2 FDFT1 FKBP8 FUNDC2 FXYD6 GAD2 GIMAP1 GIMAP5 GJB2 GOSR2 GPR37L1 HMOX1 HMOX2 HOMER3 ICMT ITGAM JAGN1 KCNJ2 KLRG1 LEPROTL1 LPAR3 MAL2 MALL MMD MOSPD3 MUCL1 MYADML2 NAT8 NINJ2 NKG7 NRM NUCB2 ORMDL1 ORMDL3 PAEP PDZK1IP1 PGAP2 PLN PLP1 PLPP4 PLPPR2 PMP22 PRB1 PTPN9 RTP2 S100A2 SACM1L SEMA4G SLC13A3 SLC2A5 SLC35A1 SLC35B1 SLC38A7 SLC39A2 SMAGP SPN STRIT1 STX1A STX7 TECR TEX264 TFRC THSD7A THSD7B TM6SF2 TMEM11 TMEM121 TMEM128 TMEM14C TMEM187 TMEM190 TMEM218 TMEM229B TMEM254 TMEM43 TMEM54 TMEM65 TMEM79 TMEM86B TMEM97 TMUB2 TNFRSF10C TNMD TRARG1 TSPO2 UBE2I VAMP1 VAMP2 VAMP3 VAMP4 VSTM1 WFDC2 YIPF6 ZDHHC15
Entrez ID		53345	200894
HPRD ID		12109	12334
Ensembl ID		ENSG00000213996	ENSG00000169379
Uniprot IDs		Q8N8A7 Q9BZW4	Q3SXY8
PDB IDs
Enriched GO Terms of Interacting Partners?
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