PLA2G1B and BGN

Data Source:
HPRD (in vitro)

		PLA2G1B	BGN
Description		phospholipase A2 group IB	biglycan
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface Secretory Granule	Extracellular Region Extracellular Space Golgi Lumen Cell Surface Transport Vesicle Extracellular Matrix Sarcolemma Lysosomal Lumen Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Phospholipase A2 Activity Signaling Receptor Binding Calcium Ion Binding Bile Acid Binding Calcium-dependent Phospholipase A2 Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)	Extracellular Matrix Structural Constituent Protein Binding Glycosaminoglycan Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Extracellular Matrix Binding
	Biological Process	Activation Of MAPK Activity Innate Immune Response In Mucosa Neutrophil Mediated Immunity Fatty Acid Biosynthetic Process Phosphatidic Acid Biosynthetic Process Actin Filament Organization Signal Transduction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Calcium Ion Transport Into Cytosol Lipid Catabolic Process Leukotriene Biosynthetic Process Antibacterial Humoral Response Neutrophil Chemotaxis Activation Of Phospholipase A2 Activity Positive Regulation Of Interleukin-8 Production Cellular Response To Insulin Stimulus Intracellular Signal Transduction Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Glucose Import Phosphatidylcholine Metabolic Process Phosphatidylglycerol Metabolic Process Positive Regulation Of Fibroblast Proliferation Arachidonic Acid Secretion Positive Regulation Of Protein Secretion Positive Regulation Of Immune Response Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Glomerular Visceral Epithelial Cell Apoptotic Process	Blood Vessel Remodeling Biological_process Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Extracellular Matrix Organization Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Bone Development Articular Cartilage Development
Pathways		Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA	A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis Dermatan sulfate biosynthesis CS/DS degradation ECM proteoglycans ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1
Drugs		Sulfasalazine Azelastine Hexane-1,6-Diol N-Tridecanoic Acid Cholic Acid P-Anisic Acid Heptanoic acid 1-O-Octyl-2-Heptylphosphonyl-Sn-Glycero-3-Phosphoethanolamine Pyruvaldehyde Lpc-Ether Niflumic acid PHOSPHONIC ACID 2-DODECANOYLAMINO-HEXYL ESTER PROPYL ESTER 1-DECYL-3-TRIFLUORO ETHYL-SN-GLYCERO-2-PHOSPHOMETHANOL Medical Cannabis
Diseases
GWAS		Bipolar disorder ( 31043756)
Interacting Genes		5 interacting genes: BGN CSF3R PLA2G2A PLAA SOCS2	17 interacting genes: - APOB APP BMP4 CCN4 COL1A1 COL1A2 COL2A1 COL4A2 DAG1 ELN HSPB2 JPH3 MFAP2 PLA2G1B TGFB1 TNF
Entrez ID		5319	633
HPRD ID		01396	02359
Ensembl ID		ENSG00000170890	ENSG00000182492
Uniprot IDs		P04054	B4DNL4 P21810
PDB IDs		1YSK 3ELO 6Q42
Enriched GO Terms of Interacting Partners?
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