SERPINE2 and COL4A3

Data Source:
HPRD (in vivo)

		SERPINE2	COL4A3
Description		serpin family E member 2	collagen type IV alpha 3 chain
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Platelet Alpha Granule Extrinsic Component Of External Side Of Plasma Membrane Neuromuscular Junction Collagen-containing Extracellular Matrix Extracellular Vesicle	Extracellular Region Collagen Type IV Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Extracellular Matrix Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Glycosaminoglycan Binding Heparin Binding	Integrin Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding Metalloendopeptidase Inhibitor Activity Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Blood Coagulation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Plasminogen Activation Negative Regulation Of Sodium Ion Transport Negative Regulation Of Endopeptidase Activity Negative Regulation Of Protein Processing Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Cerebellar Granular Layer Morphogenesis Negative Regulation Of Blood Coagulation Negative Regulation Of Cell Growth Regulation Of Cell Migration Secretion By Cell Secretory Granule Organization Negative Regulation Of Protein Catabolic Process Mating Plug Formation Negative Regulation Of Proteolysis Negative Regulation Of Smoothened Signaling Pathway Regulation Of Timing Of Cell Differentiation Positive Regulation Of Astrocyte Differentiation Detection Of Mechanical Stimulus Involved In Sensory Perception Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Innervation Seminal Vesicle Epithelium Development Negative Regulation Of Platelet Aggregation	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Adhesion Cell Surface Receptor Signaling Pathway Sensory Perception Of Sound Blood Circulation Negative Regulation Of Cell Population Proliferation Response To Glucose Negative Regulation Of Endopeptidase Activity Negative Regulation Of Angiogenesis Extracellular Matrix Organization Glomerular Basement Membrane Development Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Endothelial Cell Apoptotic Process Negative Regulation Of Vascular Endothelial Cell Proliferation
Pathways		Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Dissolution of Fibrin Clot	Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization
Drugs
Diseases			Benign familial hematuria; Thin basement membrane nephropathy Alport syndrome
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) ( 23648065) Blood protein levels ( 30072576 29875488) Cerebrospinal T-tau levels ( 28247064) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Height ( 20881960 31562340) Inflammatory biomarkers (multivariate analysis) ( 33110245) Mean platelet volume ( 32888494 27863252) Platelet-derived growth factor BB levels ( 27989323)	Advanced age-related macular degeneration ( 26691988) Central corneal thickness ( 32528159 31798171 29760442) Corneal structure ( 23291589) Diabetic nephropathy in type 1 diabetes ( 31537649) Hematuria ( 30476138) Hematuria (moderate to severe) ( 30476138) Intraocular pressure ( 29235454) Kidney disease (end stage renal disease or albuminuria) in type 1 diabetes ( 31537649) Kidney disease (reduced eGFR and albuminuria or end stage renal disease) in type 1 diabetes ( 31537649) Macroalbuminuria in type 1 diabetes ( 31537649) Macular thickness ( 30535121) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Refractive error ( 32231278) Resting heart rate ( 27798624)
Interacting Genes		8 interacting genes: COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 F2 FAM9B	17 interacting genes: ANTXR2 APP CAMK2B CD93 CERT1 DCN FBLN2 FN1 HABP2 MATN2 MFAP2 MMP9 OSM SAA1 SERPINE2 TGFBI USH2A
Entrez ID		5270	1285
HPRD ID		01510	00354
Ensembl ID		ENSG00000135919	ENSG00000169031
Uniprot IDs		A0A024R451 A0A024R498 P07093	Q01955
PDB IDs		4DY0 4DY7	5NB0
Enriched GO Terms of Interacting Partners?
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