SERPINA4 and TRIP11

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vitro)

		SERPINA4	TRIP11
Description		serpin family A member 4	thyroid hormone receptor interactor 11
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Dense Granule Lumen Extracellular Exosome	Golgi Membrane Inner Acrosomal Membrane Outer Acrosomal Membrane Nucleoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cis-Golgi Network Cytoskeleton Cilium Nuclear Speck Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity	Transcription Coactivator Activity Protein Binding Small GTPase Binding
	Biological Process	Platelet Degranulation Negative Regulation Of Endopeptidase Activity	Ventricular Septum Development Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Transcription By RNA Polymerase II Protein Glycosylation Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Organization Intraciliary Transport Involved In Cilium Assembly Positive Regulation Of Transcription, DNA-templated Cartilage Development Inner Ear Receptor Cell Stereocilium Organization Golgi Ribbon Formation Vesicle Tethering To Golgi
Pathways		Platelet degranulation	Intraflagellar transport Intra-Golgi traffic Signaling by FLT3 fusion proteins Signaling by FLT3 fusion proteins
Drugs		Zinc Copper Zinc acetate
Diseases			Achodrogenesis type IA
GWAS		Blood protein levels ( 30072576 29875488 28240269) Vaspin levels ( 22907691)	Body size at age 10 ( 32376654) FEV1 ( 30804560) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Height ( 28552196 20881960 25282103 25429064 31562340 18391950 18391951) LDL cholesterol levels x loop diuretics use interaction ( 31806883) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 26635082 30804560) Refractive error ( 32231278) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)
Interacting Genes		13 interacting genes: CTSD GADD45G ILK KLK1 KLK2 MAP4K2 MAPK6 NR4A1 RASA1 TAB1 TNFRSF14 TNNT1 YAE1	6 interacting genes: ARNT ATXN1L MYBPC2 PSMC5 RB1 THRA
Entrez ID		5267	9321
HPRD ID		01004	05143
Ensembl ID		ENSG00000100665	ENSG00000100815
Uniprot IDs		A0A024R6I9 P29622	Q15643
PDB IDs		6F02
Enriched GO Terms of Interacting Partners?
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