SERPINA4 and KLK2

Data Source:
HPRD (in vitro)

		SERPINA4	KLK2
Description		serpin family A member 4	kallikrein related peptidase 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Dense Granule Lumen Extracellular Exosome	Extracellular Region Secretory Granule Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity	Serine-type Endopeptidase Activity
	Biological Process	Platelet Degranulation Negative Regulation Of Endopeptidase Activity	Regulation Of Systemic Arterial Blood Pressure Extracellular Matrix Disassembly Zymogen Activation
Pathways		Platelet degranulation	Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Drugs		Zinc Copper Zinc acetate
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Vaspin levels ( 22907691)	Celiac disease ( 23936387) PCA3 expression level ( 23555189) Prostate cancer ( 31562322) Prostate-specific antigen levels ( 23359319 28139693) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Tandem gait ( 26219847)
Interacting Genes		13 interacting genes: CTSD GADD45G ILK KLK1 KLK2 MAP4K2 MAPK6 NR4A1 RASA1 TAB1 TNFRSF14 TNNT1 YAE1	14 interacting genes: A2M APP AR IGFBP2 POLR2A SEMG1 SEMG2 SERPINA3 SERPINA4 SERPINA5 SERPINB6 SERPINC1 SERPINE1 SERPINF2
Entrez ID		5267	3817
HPRD ID		01004	01006
Ensembl ID		ENSG00000100665	ENSG00000167751
Uniprot IDs		A0A024R6I9 P29622	A0A024R4J4 A0A024R4N3 B4DU77 P20151
PDB IDs		6F02	4NFE 4NFF
Enriched GO Terms of Interacting Partners?
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