PHYH and ACSL6

Data Source:
HPRD (in vitro)

		PHYH	ACSL6
Description		phytanoyl-CoA 2-hydroxylase	acyl-CoA synthetase long chain family member 6
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Peroxisome Peroxisomal Matrix Cytosol 9+0 Non-motile Cilium	Mitochondrial Outer Membrane Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Ferrous Iron Binding Carboxylic Acid Binding L-ascorbic Acid Binding Phytanoyl-CoA Dioxygenase Activity	Long-chain Fatty Acid-CoA Ligase Activity ATP Binding Protein Homodimerization Activity Arachidonate-CoA Ligase Activity
	Biological Process	Fatty Acid Alpha-oxidation 2-oxoglutarate Metabolic Process Protein Targeting To Peroxisome Isoprenoid Metabolic Process 2-oxobutyrate Catabolic Process Methyl-branched Fatty Acid Metabolic Process	Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Acyl-CoA Metabolic Process Lipid Biosynthetic Process Long-chain Fatty-acyl-CoA Biosynthetic Process
Pathways		Alpha-oxidation of phytanate Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins	Synthesis of very long-chain fatty acyl-CoAs
Drugs		Antihemophilic factor, human recombinant Ascorbic acid Lonoctocog alfa Moroctocog alfa
Diseases		Refsum disease; Heredopathia atactica polyneuritiformis
GWAS			Alzheimer's disease in APOE e4- carriers ( 25778476) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908 22412388) Inflammatory bowel disease ( 28067908 23128233) Perceived unattractiveness to mosquitoes ( 28199695) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		11 interacting genes: ACSL6 APP F8 FAM9B FKBP4 MAGEA11 PATJ PEX7 PHYHIP SIRPA TOM1L1	3 interacting genes: PCMTD2 PHYH ZNF655
Entrez ID		5264	23305
HPRD ID		03609	09190
Ensembl ID		ENSG00000107537	ENSG00000164398
Uniprot IDs		O14832	B2RB13 B4DFW3 Q9UKU0
PDB IDs		2A1X
Enriched GO Terms of Interacting Partners?
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