PHKA2 and UROD

Data Source:
BioGRID (two hybrid)

		PHKA2	UROD
Description		phosphorylase kinase regulatory subunit alpha 2	uroporphyrinogen decarboxylase
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Phosphorylase Kinase Complex	Nucleoplasm Cytosol
	Molecular Function	Phosphorylase Kinase Activity Protein Binding Calmodulin Binding	Uroporphyrinogen Decarboxylase Activity Protein Binding
	Biological Process	Carbohydrate Metabolic Process Glycogen Catabolic Process Generation Of Precursor Metabolites And Energy Cellular Protein Modification Process Protein Phosphorylation	Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process
Pathways		Glycogen breakdown (glycogenolysis)	Heme biosynthesis
Drugs			Coproporphyrin I Coproporphyrinogen III
Diseases		Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)	Hepatic porphyria, including: Porphyria Cutanea Tarda (PCT); VHepatoerythropoietic porphyria; Acute Intermittent Porphyria (AIP); Variegate porphyria (VP); ALA-dehydratase deficiency porphyria (ALADP); Hereditary Coproporphyria (HCP)
GWAS
Interacting Genes		5 interacting genes: PHKB PHKG2 RAF1 SMAD9 UROD	10 interacting genes: CHD3 EGFR FAF1 FBXO7 HMGXB4 LRATD2 PHKA2 PILRA TSSK3 VIM
Entrez ID		5256	7389
HPRD ID		02380	01441
Ensembl ID		ENSG00000044446	ENSG00000126088
Uniprot IDs		P46019	P06132
PDB IDs			1JPH 1JPI 1JPK 1R3Q 1R3R 1R3S 1R3T 1R3V 1R3W 1R3Y 1URO 2Q6Z 2Q71 3GVQ 3GVR 3GVV 3GVW 3GW0 3GW3
Enriched GO Terms of Interacting Partners?
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