GNG13 and RSPO4

Data Source:
BioGRID (two hybrid)

		GNG13	RSPO4
Description		G protein subunit gamma 13	R-spondin 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Dendrite	Extracellular Region
	Molecular Function	Protein Binding G-protein Beta-subunit Binding	Protein Binding Heparin Binding
	Biological Process	Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Sensory Perception Of Taste	Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Nail Development
Pathways		Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Regulation of FZD by ubiquitination
Drugs
Diseases			Anonychia congenita
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Metabolite levels ( 23823483)	Blood protein levels ( 30072576) Lean body mass ( 28552196) Logical memory (immediate recall) in Alzheimer's disease dementia ( 29274321)
Interacting Genes		39 interacting genes: ABI3 ADAMTSL4 BEX5 CCHCR1 CTAG1A CTAG1B CYSRT1 DISC1 DLG1 DLG4 EMILIN1 FTO GLRX3 GNAT3 GNB1 GNB2 GNB3 GNB4 GNB5 HAUS3 HOXA10 KRT27 KRT34 KRT37 KRT38 KRTAP9-2 LIN7B MEOX2 PAX5 PLSCR2 RASSF10 RPRM RSPO4 TEAD2 TEPSIN TRIM54 UQCC2 VPS16 WASHC3	15 interacting genes: ANKRD11 DHX57 GNG13 GPSM3 GUCD1 HGS KLHL38 LGR4 MAPK9 MKRN3 PIH1D2 STK16 USP20 ZNF330 ZNF77
Entrez ID		51764	343637
HPRD ID		12116	18788
Ensembl ID		ENSG00000127588	ENSG00000101282
Uniprot IDs		Q9P2W3	Q2I0M5
PDB IDs
Enriched GO Terms of Interacting Partners?
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