SYT17 and CEP63

Data Source:
BioGRID (two hybrid)

		SYT17	CEP63
Description		synaptotagmin 17	centrosomal protein 63
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GO Annotations	Cellular Component	Plasma Membrane Exocytic Vesicle	Spindle Pole Centrosome Centriole Cytosol
	Molecular Function	SNARE Binding Phosphatidylserine Binding Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Syntaxin Binding Clathrin Binding	Protein Binding
	Biological Process	Regulation Of Dopamine Secretion Vesicle-mediated Transport Calcium-ion Regulated Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Cell Differentiation Cellular Response To Calcium Ion Positive Regulation Of Dendrite Extension	DNA Damage Checkpoint G2/M Transition Of Mitotic Cell Cycle Centriole Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Signal Transduction In Response To DNA Damage Spindle Assembly Cell Division Ciliary Basal Body-plasma Membrane Docking De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation
Pathways			Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Alcohol dependence ( 21876473) Fruit consumption ( 32066663) Parkinson's disease ( 27182965) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Height ( 18391952) Late-onset Alzheimer's disease ( 27770636) Neurocognitive impairment in HIV-1 infection (dichotomous) ( 28447399) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)
Interacting Genes		50 interacting genes: AK8 APP APTX BLZF1 CBY2 CCDC102B CCDC33 CCDC85B CCNB1IP1 CEP63 CEP70 CHMP4A COG6 DEPDC5 EXOC8 FAM9B FRMD6 GMCL1 GOLGA2 GOLGA6A HIP1 HOOK2 IKZF1 LSM7 LZTS1 LZTS2 MAD1L1 MAJIN MCC MEOX1 MEOX2 MID2 NIF3L1 NINL PFDN5 PIBF1 PICK1 POF1B RUNDC3A SDCBP2 SNRNP35 SSX2IP TRAF2 TRIM27 TSC22D4 TSNAX VPS9D1 ZNF438 ZNF597 ZRANB1	66 interacting genes: ALOX5 ARFIP2 ARNT2 BFSP2 BRPF1 CAMKK2 CAPN7 CCDC14 CCDC187 CCHCR1 CCNI CDK1 CEP57 CEP57L1 CWF19L2 DAXX DISC1 DST DTNB DZIP3 EXOC4 EZH2 FAM161A FBF1 FEM1C GSE1 HAUS1 HGS INTS6L KANK2 KXD1 MACF1 MBIP MNS1 NCOR2 NDC80 NDEL1 NXT2 PCNX4 PIBF1 POLR3C PPP1R13B PPP4R1 RCOR3 ROGDI SMARCE1 SMC3 SNRNP70 SPTAN1 SPTBN1 SSX3 SYNE1 SYT17 TBC1D15 TBC1D22B TSG101 TSGA10IP TSHZ3 TXLNA TXLNB USHBP1 USP2 ZCCHC10 ZNF148 ZNF250 ZNF774
Entrez ID		51760	80254
HPRD ID		17425	07826
Ensembl ID		ENSG00000103528	ENSG00000182923
Uniprot IDs		H3BN78 H3BRH9 Q9BSW7	Q96MT8
PDB IDs		2ENP	6CSU 6CSV
Enriched GO Terms of Interacting Partners?
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