CEP63 and NXT2

Data Source:
BioGRID (two hybrid)

		CEP63	NXT2
Description		centrosomal protein 63	nuclear transport factor 2 like export factor 2
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Centrosome Centriole Cytosol	Nucleoplasm Cytosol Nuclear Pore Central Transport Channel Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	DNA Damage Checkpoint G2/M Transition Of Mitotic Cell Cycle Centriole Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Signal Transduction In Response To DNA Damage Spindle Assembly Cell Division Ciliary Basal Body-plasma Membrane Docking De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation	Protein Import Into Nucleus Nucleocytoplasmic Transport MRNA Transport
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Height ( 18391952) Late-onset Alzheimer's disease ( 27770636) Neurocognitive impairment in HIV-1 infection (dichotomous) ( 28447399) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)
Interacting Genes		66 interacting genes: ALOX5 ARFIP2 ARNT2 BFSP2 BRPF1 CAMKK2 CAPN7 CCDC14 CCDC187 CCHCR1 CCNI CDK1 CEP57 CEP57L1 CWF19L2 DAXX DISC1 DST DTNB DZIP3 EXOC4 EZH2 FAM161A FBF1 FEM1C GSE1 HAUS1 HGS INTS6L KANK2 KXD1 MACF1 MBIP MNS1 NCOR2 NDC80 NDEL1 NXT2 PCNX4 PIBF1 POLR3C PPP1R13B PPP4R1 RCOR3 ROGDI SMARCE1 SMC3 SNRNP70 SPTAN1 SPTBN1 SSX3 SYNE1 SYT17 TBC1D15 TBC1D22B TSG101 TSGA10IP TSHZ3 TXLNA TXLNB USHBP1 USP2 ZCCHC10 ZNF148 ZNF250 ZNF774	24 interacting genes: APP CCDC102B CEP63 DDIT4L GOLGA2 GOLGA6L9 IKZF3 LNX1 NXF1 NXF2 NXF2B NXF3 PKM PTPN3 RASSF10 REL SRPK1 SRPK2 SSBP3 STAT3 TCF4 TRIM23 USP54 ZNF655
Entrez ID		80254	55916
HPRD ID		07826	02264
Ensembl ID		ENSG00000182923	ENSG00000101888
Uniprot IDs		Q96MT8	Q9NPJ8
PDB IDs		6CSU 6CSV
Enriched GO Terms of Interacting Partners?
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