KLF13 and SREBF1

Data Source:
BioGRID (pull down)

		KLF13	SREBF1
Description		Kruppel like factor 13	sterol regulatory element binding transcription factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Golgi Membrane Chromatin Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Protein-containing Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Protein Kinase Binding Sterol Response Element Binding Protein-containing Complex Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Heart Rate By Chemical Signal Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Aging Circadian Rhythm Cholesterol Metabolic Process Insulin Receptor Signaling Pathway Lipid Biosynthetic Process Cellular Response To Starvation Response To Glucose Positive Regulation Of Triglyceride Biosynthetic Process Lipid Localization Regulation Of Lipid Storage Regulation Of Fatty Acid Metabolic Process Lung Development Intracellular Receptor Signaling Pathway Positive Regulation Of Histone Deacetylation Regulation Of Protein Stability Response To Food Response To Retinoic Acid Response To Progesterone SREBP Signaling Pathway Response To Glucagon Response To Drug MRNA Transcription By RNA Polymerase II Fat Cell Differentiation Response To Ethanol Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Secretion Response To CAMP Cellular Response To Fatty Acid Regulation Of Autophagy Of Mitochondrion Regulation Of Protein Targeting To Mitochondrion
Pathways			RORA activates gene expression FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs			Doconexent Omega-3-acid ethyl esters Omega-3 fatty acids Fish oil
Diseases
GWAS		Brain volume in infants (intracranial brain volume) ( 28763065) Deep white matter hyperintensities ( 32517579) Eosinophilic esophagitis ( 25017104) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 29403010 32888494) Psoriasis ( 28537254) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Triglyceride levels ( 32203549) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)	Coffee consumption ( 31046077) Eosinophil counts ( 32888494) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Parkinson's disease ( 21738487) Resting heart rate ( 27798624) Schizophrenia ( 28991256 25056061 29483656) TB-LM or TBLH-BMD (pleiotropy) ( 28743860) White blood cell count ( 32888494)
Interacting Genes		9 interacting genes: CREBBP EP300 KAT2B PCBD1 PRPF4B SERPINH1 SIN3A SREBF1 SREBF2	40 interacting genes: AR ATXN1 ATXN1L CDK8 CREBBP EP300 ESR1 ESR2 FBXW7 GSK3B HNF4A ID2 ID3 KLF13 LMNA MAPK1 MAPK3 MED1 MED12 MED13 MED14 MED17 MED23 MED24 MED25 MED26 MED6 MED7 MTNR1B NR0B1 NR5A2 PLK1 PRMT5 SMARCD3 SP1 SUMO1 TWIST2 UBE2I YY1 ZBTB7C
Entrez ID		51621	6720
HPRD ID		05620	01701
Ensembl ID		ENSG00000169926	ENSG00000072310
Uniprot IDs		Q9Y2Y9 X5DNR2	A8MTU8 B3KR77 P36956
PDB IDs			1AM9
Enriched GO Terms of Interacting Partners?
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