GET4 and CAPNS1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GET4	CAPNS1
Description		guided entry of tail-anchored proteins factor 4	calpain small subunit 1
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GO Annotations	Cellular Component	Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol BAT3 Complex	Cytosol Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Protein Binding Chaperone Binding	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding
	Biological Process	Protein Insertion Into ER Membrane Cytoplasmic Sequestering Of Protein Tail-anchored Membrane Protein Insertion Into ER Membrane Maintenance Of Unfolded Protein Involved In ERAD Pathway	Proteolysis Positive Regulation Of Cell Population Proliferation Regulation Of Macroautophagy Extracellular Matrix Disassembly Cornification
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Degradation of the extracellular matrix Degradation of the extracellular matrix Formation of the cornified envelope Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs			PD150606
Diseases
GWAS		PR interval ( 32439900)
Interacting Genes		29 interacting genes: AKT1 ATP5PD BAG6 C1orf109 CAPNS1 CDKN1A CEP126 DUSP21 EEF1G ENKD1 FBN1 FLYWCH2 GET3 GIT2 KAT5 KIFC2 KRTAP9-3 NUP85 PLK1 PRKAB2 PRKCSH PTMS SDCBP SEC61B SNCAIP SOD2 TMEM256 TTR UBAC2	20 interacting genes: AGTRAP ARHGEF6 ARR3 ATP5MF CAPN1 CAPN2 CAST CDC42 CDK4 DRG1 F2RL1 GET4 GNB2 IL2RG LRRCC1 PPARGC1A RAB1A STAT3 TERF1 TRAF5
Entrez ID		51608	826
HPRD ID		12909	00240
Ensembl ID		ENSG00000239857	ENSG00000126247
Uniprot IDs		Q7L5D6	A0A0C4DGQ5 P04632
PDB IDs		6AU8	1KFU 1KFX 4PHJ 4PHK 4PHM 4WQ2 4WQ3 5D69 6QLB
Enriched GO Terms of Interacting Partners?
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