PDE4A and AIP

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		PDE4A	AIP
Description		phosphodiesterase 4A	aryl hydrocarbon receptor interacting protein
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane Membrane Ruffle Membrane Perinuclear Region Of Cytoplasm	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Aryl Hydrocarbon Receptor Complex
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding CAMP Binding Metal Ion Binding	Transcription Coactivator Activity Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Transcription Factor Binding Aryl Hydrocarbon Receptor Binding GAF Domain Binding Unfolded Protein Binding
	Biological Process	CAMP Catabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Sensory Perception Of Smell Regulation Of Protein Kinase A Signaling Cellular Response To Drug Regulation Of CAMP-mediated Signaling	Protein Peptidyl-prolyl Isomerization Protein Targeting To Mitochondrion Xenobiotic Metabolic Process Regulation Of Protein Kinase A Signaling Protein Maturation By Protein Folding Interleukin-12-mediated Signaling Pathway Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity
Pathways		DARPP-32 events G alpha (s) signalling events	Aryl hydrocarbon receptor signalling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs		Caffeine Theophylline Dyphylline Enprofylline Dipyridamole Iloprost Oxtriphylline Amrinone Roflumilast Piclamilast Crisaborole Ibudilast Propentofylline Drotaverine (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid Tofisopam Trapidil
Diseases
GWAS		Blood protein levels ( 28240269) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Inflammatory skin disease ( 25574825) Multiple sclerosis ( 31604244) Plateletcrit ( 32888494)	Apolipoprotein A1 levels ( 32203549) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Refractive error ( 32231278) Urate levels ( 31578528)
Interacting Genes		6 interacting genes: AIP CYB561D2 LYN OSGIN1 PFKFB1 PIAS4	18 interacting genes: AHR ARNT CLEC7A CSNK2A1 EGFR ERBB2 GNA13 GNAQ HSP90AA1 HTR6 IKBKG IRF7 PDE4A PPARA PTGES3 STIP1 TNNI3K TOMM20
Entrez ID		5141	9049
HPRD ID		02527	10408
Ensembl ID		ENSG00000065989	ENSG00000110711
Uniprot IDs		P27815	G9I2H4 O00170
PDB IDs		2QYK 3I8V 3TVX	2LKN 4AIF 4APO
Enriched GO Terms of Interacting Partners?
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