DTL and TOB1

Data Source:
BioGRID (enzymatic study)

		DTL	TOB1
Description		denticleless E3 ubiquitin protein ligase homolog	transducer of ERBB2, 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Centrosome Cytosol Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Nuclear Membrane Cul4-RING E3 Ubiquitin Ligase Complex	Nucleus Cytoplasm CCR4-NOT Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding	Transcription Corepressor Activity Protein Binding Receptor Tyrosine Kinase Binding SMAD Binding
	Biological Process	Protein Polyubiquitination DNA Replication Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Response To UV Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Translesion Synthesis DNA Damage Response, Detection Of DNA Damage Post-translational Protein Modification Positive Regulation Of Protein Catabolic Process Rhythmic Process Regulation Of Cell Cycle Signal Transduction Involved In G2 DNA Damage Checkpoint	Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Negative Regulation Of Translation Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Pathways		Recognition of DNA damage by PCNA-containing replication complex Neddylation
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Birth weight ( 31043758 27680694) Height ( 20881960) Large artery stroke ( 28265093) Nickel levels ( 26025379) Plateletcrit ( 32888494)	Blood protein levels ( 28240269)
Interacting Genes		17 interacting genes: ATR CDK1 CDK2 CDKN1A CDT1 CHEK1 DDB1 KAT2A KMT5A PCNA POLD4 RBX1 TDG TOB1 TP53 UBE2D1 UBE2N	19 interacting genes: APP CDC7 CNOT7 CORO7 DTL ERBB2 MAPK1 MAPK9 MARCKS PABPC1 SCMH1 SETDB1 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD6 SMAD9
Entrez ID		51514	10140
HPRD ID		17952	09273
Ensembl ID		ENSG00000143476	ENSG00000141232
Uniprot IDs		B4E0E6 Q9NZJ0	P50616
PDB IDs		6QC0	2D5R 2Z15 5CI8 5CI9
Enriched GO Terms of Interacting Partners?
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