TOB1 and MARCKS

Data Source:
HPRD (in vitro, two hybrid)

		TOB1	MARCKS
Description		transducer of ERBB2, 1	myristoylated alanine rich protein kinase C substrate
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm CCR4-NOT Complex	Cytoplasm Centrosome Plasma Membrane Focal Adhesion Cell Cortex Actin Cytoskeleton Actin Filament Bundle Germinal Vesicle Extracellular Exosome
	Molecular Function	Transcription Corepressor Activity Protein Binding Receptor Tyrosine Kinase Binding SMAD Binding	Protein Kinase C Binding Calmodulin Binding Identical Protein Binding Actin Filament Binding
	Biological Process	Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Negative Regulation Of Translation Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay	Actin Filament Organization Central Nervous System Development Actin Filament Bundle Assembly Actin Crosslink Formation
Pathways			Acetylcholine regulates insulin secretion
Drugs
Diseases
GWAS		Blood protein levels ( 28240269)	Bipolar disorder (body mass index interaction) ( 24322204) Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy ( 26460308) Household income ( 31844048) Household income (MTAG) ( 31844048) Type 2 diabetes ( 25760438)
Interacting Genes		19 interacting genes: APP CDC7 CNOT7 CORO7 DTL ERBB2 MAPK1 MAPK9 MARCKS PABPC1 SCMH1 SETDB1 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD6 SMAD9	14 interacting genes: CALM2 CCNE1 CDK1 CDK2 CDK4 CTSB NMT1 PKN1 PRKCA PRKCB PRKCZ RHOU SPP1 TOB1
Entrez ID		10140	4082
HPRD ID		09273	07519
Ensembl ID		ENSG00000141232	ENSG00000277443
Uniprot IDs		P50616	P29966 Q6NVI1
PDB IDs		2D5R 2Z15 5CI8 5CI9
Enriched GO Terms of Interacting Partners?
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