RTCB and MIR16-1

Data Source:
BioGRID (unspecified method)

		RTCB	MIR16-1
Description		RNA 2',3'-cyclic phosphate and 5'-OH ligase	microRNA 16-1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Intracellular Membrane-bounded Organelle TRNA-splicing Ligase Complex	Extracellular Space Extracellular Exosome Extracellular Vesicle
	Molecular Function	RNA Binding RNA Ligase (ATP) Activity Protein Binding GTP Binding Vinculin Binding Metal Ion Binding	RNA Polymerase II Complex Binding MRNA 3'-UTR Binding MRNA Binding Involved In Posttranscriptional Gene Silencing
	Biological Process	TRNA Exon Ligation Utilizing 2',3' Cyclic Phosphate Of 5'-exon As Source Of Linkage Phosphate TRNA Splicing, Via Endonucleolytic Cleavage And Ligation	Branching Involved In Blood Vessel Morphogenesis Negative Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Angiogenesis Negative Regulation Of NF-kappaB Transcription Factor Activity Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Translation Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Inflammatory Response Cellular Response To Glucose Stimulus Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Placenta Blood Vessel Development Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Trophoblast Cell Migration Negative Regulation Of Mesenchymal Stem Cell Proliferation Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Cell Chemotaxis To Fibroblast Growth Factor Negative Regulation Of Endothelial Cell Chemotaxis To Vascular Endothelial Growth Factor Positive Regulation Of Connective Tissue Replacement Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		tRNA processing in the nucleus
Drugs		Sucrose
Diseases
GWAS		Dimensional psychopathology (Arousal) ( 29496196) Dimensional psychopathology (Negative) ( 29496196)
Interacting Genes		75 interacting genes: CRK ESR1 LINC01554 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I	71 interacting genes: APOBEC3B C1QBP CPSF7 CRTAP DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EIF2AK2 EPRS1 ERAL1 FAM98A FAM98B FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KNOP1 LARP7 LIN28A LRPPRC MATR3 MSI2 NONO NUDT21 PDCD11 PGAM5 PRMT1 PTBP1 PTBP3 PUF60 RARS1 RBFOX2 RBM14 RBM47 RTCA RTCB SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SUGP2 SYNCRIP TAF15 TRA2A TRA2B UPF1 USP36 UTP20 YBX1 YBX2 YBX3 ZFR ZNF346
Entrez ID		51493	406950
HPRD ID		13695
Ensembl ID		ENSG00000100220	ENSG00000208006
Uniprot IDs		Q9Y3I0
PDB IDs
Enriched GO Terms of Interacting Partners?
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