PDE6G and FNBP1

Data Source:
HPRD (two hybrid, in vitro)

		PDE6G	FNBP1
Description		phosphodiesterase 6G	formin binding protein 1
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GO Annotations	Cellular Component	Plasma Membrane Photoreceptor Outer Segment Membrane Photoreceptor Disc Membrane	Lysosome Cytosol Cytoskeleton Plasma Membrane Clathrin-coated Pit Cell Cortex Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Spectrin Binding CGMP Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	Protein Binding Lipid Binding Identical Protein Binding
	Biological Process	Activation Of MAPK Activity Wnt Signaling Pathway, Calcium Modulating Pathway Visual Perception Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Negative Regulation Of Catalytic Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of G Protein-coupled Receptor Signaling Pathway	Endocytosis Signal Transduction Membrane Organization
Pathways		Activation of the phototransduction cascade Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Ca2+ pathway Ca2+ pathway	Clathrin-mediated endocytosis
Drugs		Sildenafil Vardenafil 3-isobutyl-1-methyl-7H-xanthine
Diseases		Retinitis pigmentosa (RP)
GWAS		Blond vs. brown/black hair color ( 30531825) High myopia ( 31816047) Refractive error ( 32231278)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Gut microbiota relative abundance (unassigned genus belonging to family Clostridiales) ( 33208821) LDL peak particle diameter (total fat intake interaction) ( 26112879) Pediatric autoimmune diseases ( 26301688) Physiological dysregulation (Mahalanobis distance) ( 32235003)
Interacting Genes		11 interacting genes: BHLHE40 DNM2 FNBP1 GNAO1 GRB2 GRK2 L3MBTL3 MAPK3 PRKAB2 SRC TRIP10	13 interacting genes: AGTR1 AKAP9 ARHGAP17 CBL CDC42 DNM1 FASLG ITSN1 PDE6G RND2 SNX2 TNKS WASL
Entrez ID		5148	23048
HPRD ID		08914	10446
Ensembl ID		ENSG00000185527	ENSG00000187239
Uniprot IDs		P18545	B7ZL13 B7ZL14 Q96RU3
PDB IDs		3JWR	2EFL
Enriched GO Terms of Interacting Partners?
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