PDE4D and SRC

  • Data Source:
  • BioGRID (far western blotting)

PDE4D

SRC

Description phosphodiesterase 4D SRC proto-oncogene, non-receptor tyrosine kinase
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) ( 23648065)
  • Amygdala volume ( 31530798)
  • Asthma ( 19426955)
  • Brain morphology (MOSTest) ( 32665545)
  • Breast cancer ( 29059683 23535729)
  • Chronotype ( 30696823)
  • Cognitive function ( 28808816)
  • Cortical surface area (MOSTest) ( 32665545)
  • Esophageal cancer ( 21642993)
  • Esophageal squamous cell carcinoma ( 25129146)
  • Forced expiratory volume in 1 second (occupational environmental exposures interaction) ( 25979521)
  • General cognitive ability ( 29844566)
  • HDL cholesterol levels ( 32203549)
  • Immune response to smallpox vaccine (IL-6) ( 22610502)
  • Intelligence (MTAG) ( 29326435)
  • Mitochondrial DNA levels ( 30326835)
  • Neuroticism ( 17667963)
  • Obesity-related traits ( 23251661)
  • Obsessive-compulsive disorder ( 30456828)
  • Plasma parathyroid hormone levels ( 30134803)
  • Post bronchodilator FEV1/FVC ratio ( 26634245)
  • Response to antipsychotic treatment ( 23241943)
  • Sleep duration (long sleep) ( 30846698)
  • Sleep-related phenotypes ( 17903308)
  • Subcortical volume (MOSTest) ( 32665545)
  • Thyroid stimulating hormone levels ( 32769997)
Interacting Genes 28 interacting genes: ABL1 AKAP6 APP ARRB1 ARRB2 COIL CSNK1A1 FBXO7 FYN GOLGA8EP GOLGA8F GRB2 GSK3B HRAS LYN MAGEA6 MAPK1 MDM2 PAFAH1B1 PDE4DIP PIAS4 PIK3R1 PRKACA RACK1 SPTAN1 SRC TRAF1 TRIM23 300 interacting genes: ABL1 ACTN1 ADAM12 ADAM15 ADRB2 ADRB3 AFAP1 AFAP1L2 AGAP1 AKT1 ALDOB ANKRD11 ANXA1 ANXA2 ANXA7 AR ARHGAP1 ARHGAP17 ARHGAP32 ARHGAP35 ARR3 ASAP1 ATG9A ATP2B4 AXL BAAT BCAR1 BCCIP BCR BMX CA3 CASP8 CAV1 CAV2 CBL CBLC CCDC180 CCNA1 CD2AP CD33 CD36 CD44 CD46 CD59 CDC25A CDC37 CDCP1 CDH5 CDK1 CDK5 CDKN1B CEACAM1 CEACAM3 CFL1 CHUK CLTC CNTNAP1 COASY CORO7 CRMP1 CSK CTNNB1 CTNND1 CTSV CTTN DAB1 DAB2 DAG1 DAPP1 DDR2 DGKA DGKZ DLG4 DNM1 DNM2 DOK1 DOK2 DOK4 EFNA5 EFNB1 EFNB2 EFS EGFR EGLN1 EMD ENO1 EPHA3 EPHA4 EPHB2 EPS8 ERBB2 ERBB3 ERBB4 ERRFI1 ESR1 ESR2 ETS1 ETS2 EVL FANCC FARP2 FASLG FBP2 FBXO5 FGR FHIT FLNA FLT3 FOXO1 FRS2 FYB1 FZR1 GAB1 GAB2 GAB3 GALNT12 GFAP GIT1 GJA1 GJB1 GRB10 GRB2 GRIN2A GRIN2B GRK2 GTF2I GUCY2C HDAC3 HEMGN HLA-A HLA-B HNF1A HNRNPK HRAS HSP90AA1 IGF1R IKBKB IKBKG IL6R INPPL1 INSR ITGB3 ITK JUP KCNA5 KCNB1 KCNQ5 KDR KHDRBS1 KIFAP3 KIT LRP1 LYN MAP2 MAP2K1 MAPK15 MAPK3 MAPK8IP3 MAPRE1 MAPT MATK MDM2 MED28 MET MICAL1 MPZL1 MST1R MT-ND2 MUC1 MYLK NANS NCOA6 NEDD4 NFKBIA NMT1 NOS2 NPHS1 NR1I2 NR1I3 NR3C1 P2RY2 PAK2 PDCD6IP PDE4D PDE6G PDGFRB PDPK1 PECAM1 PELP1 PGR PIK3R1 PIK3R3 PIP5K1C PKD1 PLCG1 PLD1 PLD2 PLSCR1 PPARD PPARGC1B PPP2CB PRKACA PRKCA PRKCD PRKCE PRKCH PRKCI PRKCZ PRKD1 PROM1 PTK2 PTK2B PTPA PTPN1 PTPN11 PTPN18 PTPN2 PTPN21 PTPN6 PTPRA PTPRC PTPRE PXN RACK1 RAF1 RARA RASA1 RASGRF1 RET RGS16 RPL10 RPS6KA3 RPS6KB1 RPS6KB2 RXRA SH2D3C SH3BP1 SH3PXD2A SHB SHC1 SKAP1 SKAP2 SLC9A2 SMARCB1 SMARCE1 SNCA SORBS1 SPTAN1 SRCIN1 SRF SRPK2 STAP2 STAT1 STAT3 STAT5A STAT5B STAT6 STUB1 STX17 SYK SYN1 TAMALIN TERT THRA THRB TIAM1 TMPO TNFRSF11A TNFRSF1A TNK2 TP53 TRAF1 TRAF3 TRAF6 TRAT1 TRIM50 TRIM7 TRIP10 TRIP6 TRMO TRPC6 TRPV4 TUB TXK TYRO3 USP8 VCL VDR VIL1 WAS WASL WBP11 WWOX XPA YTHDC1 YWHAB YWHAE YWHAG YWHAH ZNF189
Entrez ID 5144 6714
HPRD ID 02530 01819
Ensembl ID ENSG00000113448 ENSG00000197122
Uniprot IDs A0A140VJR0 Q08499 P12931
PDB IDs 1E9K 1MKD 1OYN 1PTW 1Q9M 1TB7 1TBB 1XOM 1XON 1XOQ 1XOR 1Y2B 1Y2C 1Y2D 1Y2E 1Y2K 1ZKN 2FM0 2FM5 2PW3 2QYN 3G4G 3G4I 3G4K 3G4L 3G58 3IAD 3IAK 3K4S 3SL3 3SL4 3SL5 3SL6 3SL8 3V9B 4OGB 4W1O 4WCU 5K1I 5K32 5LBO 5TKB 5WH5 5WH6 5WQA 6AKR 6BOJ 6F6U 6F8R 6F8T 6F8U 6F8V 6F8W 6F8X 6FDC 6FDI 6FE7 6FEB 6FET 6FT0 6FTA 6FTW 6FW3 6HWO 6IAG 6IBF 6IM6 6IMB 6IMD 6IMI 6IMO 6IMR 6IMT 6IND 6INK 6INM 6KJZ 6KK0 6NJH 6NJI 6NJJ 6RCW 6ZBA 1A07 1A08 1A09 1A1A 1A1B 1A1C 1A1E 1FMK 1HCS 1HCT 1KSW 1O41 1O42 1O43 1O44 1O45 1O46 1O47 1O48 1O49 1O4A 1O4B 1O4C 1O4D 1O4E 1O4F 1O4G 1O4H 1O4I 1O4J 1O4K 1O4L 1O4M 1O4N 1O4O 1O4P 1O4Q 1O4R 1SHD 1Y57 1YI6 1YOJ 1YOL 1YOM 2BDF 2BDJ 2H8H 2SRC 3VRO 3ZMP 3ZMQ 4F59 4F5A 4F5B 4HXJ 4K11 4MXO 4MXX 4MXY 4MXZ 6ATE 6C4S 6E6E 6EHJ
Enriched GO Terms of Interacting Partners?
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