PDE4D and MAGEA6

Data Source:
BioGRID (two hybrid)

		PDE4D	MAGEA6
Description		phosphodiesterase 4D	MAGE family member A6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Microtubule Organizing Center Cytosol Plasma Membrane Voltage-gated Calcium Channel Complex Apical Plasma Membrane Calcium Channel Complex Perinuclear Region Of Cytoplasm	Cellular_component
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding Enzyme Binding CAMP Binding Beta-2 Adrenergic Receptor Binding Ion Channel Binding Metal Ion Binding ATPase Binding Scaffold Protein Binding Heterocyclic Compound Binding	Molecular_function Protein Binding
	Biological Process	Regulation Of Heart Rate CAMP Catabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of Signaling Receptor Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum CAMP-mediated Signaling Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-5 Production Negative Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of Heart Contraction T Cell Receptor Signaling Pathway Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Establishment Of Endothelial Barrier Adrenergic Receptor Signaling Pathway Regulation Of Cardiac Muscle Cell Contraction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Positive Regulation Of Heart Rate Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of Relaxation Of Cardiac Muscle	Biological_process
Pathways		DARPP-32 events G alpha (s) signalling events
Drugs		Adenosine phosphate Caffeine Caffeine Dyphylline Iloprost Amrinone Roflumilast Piclamilast Rolipram 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester 2-[3-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Propylamino]-2-Hydroxymethyl-Propane-1,3-Diol Zardaverine 1-(4-Aminophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester (S)-Rolipram Cilomilast (R)-Rolipram 3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester 1-(4-Methoxyphenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Crisaborole Ibudilast Tetomilast Exisulind (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one 3,5-DIMETHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER 3-isobutyl-1-methyl-7H-xanthine 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid Trapidil
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) ( 23648065) Amygdala volume ( 31530798) Asthma ( 19426955) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683 23535729) Chronotype ( 30696823) Cognitive function ( 28808816) Cortical surface area (MOSTest) ( 32665545) Esophageal cancer ( 21642993) Esophageal squamous cell carcinoma ( 25129146) Forced expiratory volume in 1 second (occupational environmental exposures interaction) ( 25979521) General cognitive ability ( 29844566) HDL cholesterol levels ( 32203549) Immune response to smallpox vaccine (IL-6) ( 22610502) Intelligence (MTAG) ( 29326435) Mitochondrial DNA levels ( 30326835) Neuroticism ( 17667963) Obesity-related traits ( 23251661) Obsessive-compulsive disorder ( 30456828) Plasma parathyroid hormone levels ( 30134803) Post bronchodilator FEV1/FVC ratio ( 26634245) Response to antipsychotic treatment ( 23241943) Sleep duration (long sleep) ( 30846698) Sleep-related phenotypes ( 17903308) Subcortical volume (MOSTest) ( 32665545) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		28 interacting genes: ABL1 AKAP6 APP ARRB1 ARRB2 COIL CSNK1A1 FBXO7 FYN GOLGA8EP GOLGA8F GRB2 GSK3B HRAS LYN MAGEA6 MAPK1 MDM2 PAFAH1B1 PDE4DIP PIAS4 PIK3R1 PRKACA RACK1 SPTAN1 SRC TRAF1 TRIM23	74 interacting genes: ACOT7 ACTN3 AKAP9 ANKRD26P1 APOA4 ARFIP1 ATP6V1G1 ATPAF2 BCL7B BET1 BFSP2 BOLA3 C1orf216 CAMTA2 CBFA2T2 CCDC146 CCDC185 CCDC187 CCDC24 COL4A6 CTF1 DLGAP3 DLGAP4 DNTTIP1 ELMOD3 EXOC5 FAM214A FRMPD1 GADD45GIP1 GCSH GFOD1 HAUS1 HLA-DRB4 HNRNPM IQUB KIF27 KLHL38 LCORL LIN37 LIN52 LSM2 MCM7 MCRS1 MED21 MID2 MIPOL1 MORN3 MSGN1 NCK2 NOSTRIN PCBD2 PDE4D RASSF10 RASSF4 RCOR3 REX1BD RPL37A RUSC1 S100A14 S100A9 SH2D4A SMARCD1 SNAP47 SNX4 SON STAMBPL1 STX5 TRIM26 TRIM28 TSPYL6 TULP3 TXNDC9 XRCC4 ZNF76
Entrez ID		5144	4105
HPRD ID		02530	02168
Ensembl ID		ENSG00000113448	ENSG00000197172
Uniprot IDs		A0A140VJR0 Q08499	P43360
PDB IDs		1E9K 1MKD 1OYN 1PTW 1Q9M 1TB7 1TBB 1XOM 1XON 1XOQ 1XOR 1Y2B 1Y2C 1Y2D 1Y2E 1Y2K 1ZKN 2FM0 2FM5 2PW3 2QYN 3G4G 3G4I 3G4K 3G4L 3G58 3IAD 3IAK 3K4S 3SL3 3SL4 3SL5 3SL6 3SL8 3V9B 4OGB 4W1O 4WCU 5K1I 5K32 5LBO 5TKB 5WH5 5WH6 5WQA 6AKR 6BOJ 6F6U 6F8R 6F8T 6F8U 6F8V 6F8W 6F8X 6FDC 6FDI 6FE7 6FEB 6FET 6FT0 6FTA 6FTW 6FW3 6HWO 6IAG 6IBF 6IM6 6IMB 6IMD 6IMI 6IMO 6IMR 6IMT 6IND 6INK 6INM 6KJZ 6KK0 6NJH 6NJI 6NJJ 6RCW 6ZBA
Enriched GO Terms of Interacting Partners?
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