TLR7 and GRAMD1A

Data Source:
BioGRID (two hybrid)

		TLR7	GRAMD1A
Description		toll like receptor 7	GRAM domain containing 1A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosome Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Endosome Membrane Integral Component Of Membrane Early Phagosome Endolysosome Membrane Receptor Complex	Autophagosome Cytosol Plasma Membrane Integral Component Of Membrane Intrinsic Component Of Endoplasmic Reticulum Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytoplasmic Vesicle Organelle Membrane Contact Site Endoplasmic Reticulum-plasma Membrane Contact Site
	Molecular Function	Double-stranded RNA Binding Single-stranded RNA Binding Transmembrane Signaling Receptor Activity Drug Binding SiRNA Binding Pattern Recognition Receptor Activity	Protein Binding Cholesterol Binding Cholesterol Transfer Activity
	Biological Process	Microglial Cell Activation Regulation Of Protein Phosphorylation Toll-like Receptor Signaling Pathway Inflammatory Response Immune Response I-kappaB Kinase/NF-kappaB Signaling I-kappaB Phosphorylation Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Toll-like Receptor 7 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Innate Immune Response Positive Regulation Of Inflammatory Response Defense Response To Virus Cellular Response To Mechanical Stimulus Positive Regulation Of NIK/NF-kappaB Signaling	Autophagy Sterol Transport Cellular Response To Cholesterol Intermembrane Lipid Transfer
Pathways		Trafficking and processing of endosomal TLR Toll Like Receptor 7/8 (TLR7/8) Cascade Potential therapeutics for SARS TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome
Drugs		Imiquimod Hydroxychloroquine Isatoribine ANA971 Golotimod Resiquimod
Diseases
GWAS		Celiac disease ( 20190752)	Cognitive decline (age-related) ( 28078323) Hippocampal volume in Alzheimer's disease dementia ( 29274321)
Interacting Genes		2 interacting genes: GRAMD1A MYD88	4 interacting genes: CCR1 GMCL1 MAL TLR7
Entrez ID		51284	57655
HPRD ID		02295	11153
Ensembl ID		ENSG00000196664	ENSG00000089351
Uniprot IDs		B2R9N9 Q9NYK1	B3KQF7 B3KUH3 M0QZ12 Q96CP6
PDB IDs
Enriched GO Terms of Interacting Partners?
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